1. Vitex agnus-castus essential oil affects thyroid C cells and bone metabolism in middle-aged male rats
- Author
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Jasmina Pantelic, Verica Milošević, Svetlana Trifunović, Branka Šošić-Jurjević, Ivana Medigović, B. Filipović, and Vladimir Ajdzanovic
- Subjects
medicine.medical_specialty ,Osteoporosis ,bone ,Vitex agnus-castus ,essential oil ,Bone resorption ,law.invention ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,medicine ,Essential oil ,030304 developmental biology ,thyroid C cells ,0303 health sciences ,lcsh:Veterinary medicine ,General Veterinary ,biology ,business.industry ,Thyroid ,medicine.disease ,biology.organism_classification ,3. Good health ,Endocrinology ,medicine.anatomical_structure ,Calcitonin ,030220 oncology & carcinogenesis ,lcsh:SF600-1100 ,business ,Hormone - Abstract
Ageing in men is accompanied by an increased occurrence of osteoporosis, but traditional hormonal replacement therapy elevates the risk of developing endocrine cancer. Vitex agnus-castus L. (Vac) essential oil is commonly used as an alternative therapy for ageing symptoms in both men and women. It is known that calcitonin (CT), thyroid C cell hormone, inhibits bone resorption. The purpose of this experimental study was to investigate the influence of Vac essential oil administration on the immunohistomorphometric features of thyroid C cells and bone metabolism in 16-month-old male Wistar rats. The first group of animals (n=8) was treated subcutaneously (s.c.) with 60 mg/kg of Vac essential oil once a day for 3 weeks. Control animals (n=8) received sterile olive oil s.c. by the same schedule. After Vac treatment significant increases (p
- Published
- 2013
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