1. Palliative treatment of hepatocellular carcinoma by chemoembolization.
- Author
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Poyanli A, Rozaneş I, Acunaş B, and Sencer S
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Agents administration & dosage, Antineoplastic Agents therapeutic use, Carcinoma, Hepatocellular diagnostic imaging, Carcinoma, Hepatocellular mortality, Catheterization, Peripheral, Contrast Media administration & dosage, Doxorubicin administration & dosage, Doxorubicin therapeutic use, Female, Gelatin Sponge, Absorbable administration & dosage, Gelatin Sponge, Absorbable therapeutic use, Humans, Infusions, Intra-Arterial, Iodized Oil administration & dosage, Liver Neoplasms diagnostic imaging, Liver Neoplasms mortality, Male, Middle Aged, Mitomycin administration & dosage, Mitomycin therapeutic use, Prognosis, Radiography, Survival Rate, Carcinoma, Hepatocellular therapy, Chemoembolization, Therapeutic, Liver Neoplasms therapy, Palliative Care
- Abstract
Purpose: The efficacy of transcatheter arterial chemoembolization (TACE) and the correlation between iodized oil uptake pattern and tumor response were investigated in cases with inoperable hepatocellular carcinoma (HCC)., Material and Methods: TACE, using sequential intra-arterial doxorubicin, mitomycin, iodized oil and gelatin sponge particles, was used to treat patients with inoperable HCC localized to the liver. One hundred and two patients (aged 16-80) were treated in this manner from 1995 to 2001. The objective response was determined by sequential CT. Iodized oil uptake pattern as well as the relationship between uptake pattern and tumor response was evaluated in each case., Results: The one-year survival rate was 46%. Tumor response was found to be better in cases with dense and peripheral iodized oil uptake in comparison to those displaying scarce and patchy iodized oil uptake., Conclusion: TACE is an efficient and safe palliative treatment for inoperable HCC with prolonged survival and good life quality. Iodized oil uptake pattern can be considered a good prognostic marker.
- Published
- 2001
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