1. Lack of seasonal variation in pediatric lumbar cerebrospinal fluid neurotransmitter metabolite concentrations.
- Author
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Swedo SE, Kruesi MJ, Leonard HL, Hamburger SD, Cheslow DL, Stipetic M, and Potter WZ
- Subjects
- Adolescent, Attention Deficit Disorder with Hyperactivity diagnosis, Child, Child Behavior Disorders diagnosis, Female, Humans, Male, Obsessive-Compulsive Disorder diagnosis, Attention Deficit Disorder with Hyperactivity cerebrospinal fluid, Child Behavior Disorders cerebrospinal fluid, Glycols cerebrospinal fluid, Homovanillic Acid cerebrospinal fluid, Hydroxyindoleacetic Acid cerebrospinal fluid, Methoxyhydroxyphenylglycol cerebrospinal fluid, Obsessive-Compulsive Disorder cerebrospinal fluid, Seasons
- Abstract
Seasonal variation of cerebrospinal fluid (CSF) monoamines, particularly 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) has been reported for psychiatrically ill and normal adults. Circannual variability was examined for a group of 72 children (mean age = 159.4 +/- 40.3 (SD), range 77-238 months), with a primary diagnosis of obsessive-compulsive disorder (OCD) or disruptive behavior disorder (DBD) (attention deficit disorder, oppositional disorder and/or conduct disorder), from whom CSF had been obtained systematically. There were no seasonal differences in mean concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), HVA, or 5-HIAA, either for the group as a whole, for the separate diagnostic (OCD vs DBD) categories or for the pre-pubertal subgroup. Log-corrected HVA concentrations for the Tanner IV and V subgroup differed by season with summer concentrations less than those of fall (P = 0.06) and winter (P = 0.005). The results suggest that pubertal changes may play a role in any expression of circannual variability.
- Published
- 1989
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