1. Characterization of oxidative phenotype in a pediatric population of Tlaltizapan, Morelos, Mexico.
- Author
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Flores-Pérez, Janett, Juárez-Olguín, Hugo, Flores-Pérez, Carmen, Barranco-Garduño, Marcela, Cruz-Reyes, Irma, González-Zamora, José Francisco, Murata, Chiharu, and Castillo-Cruz, Rocío
- Subjects
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DRUG metabolism -- Evaluation , *CYTOCHROME P-450 , *DEXTROMETHORPHAN , *PHARMACOGENOMICS , *CHILDREN'S health , *GENETIC polymorphisms - Abstract
Background: Genetic polymorphisms play an important role in the response to a drug regimen, based on the metabolic rate, which determines the interindividual variability. Quantitative differences in the cytochrome P450 expression, specially CYP2D6, can be assayed by means of a drug metabolism such as that of dextromethorphan. Aim: To characterize the oxidative phenotype of a pediatric population in Tlaltizapan, Morelos, using dextromethorphan as a metabolic probe. Materials and methods: This prospective, transversal, descriptive and experimental study was performed in a Mexican Rural Research Centre, located in Tlaltizapan, Morelos, a dependence of the National Institute of Pediatrics. It includes the phenotyping of a healthy pediatric population by evaluating their urinary excretion of dextromethorphan and its metabolites. Results: Five children (29%) of the 17-subject population evaluated, were slow metabolizers, while the remaining 12 children (71%) were non-slow or fast metabolizers. Conclusion: Clinically the type of metabolism within a population, whether slow or fast, indicates that individuals in both extremes of the histogram are in high risk of having adverse reactions to drugs, or poor developing or failed therapeutic response receiving when CYP2D6-metabolized drugs. [ABSTRACT FROM AUTHOR]
- Published
- 2008