1. Meglumine antimoniate-induced DRESS: original case with a positive skin test.
- Author
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Chaabane A, Romdhane HB, Brahim HB, Fredj NB, Chadli Z, Boughattas NA, Chakroun M, and Aouam K
- Subjects
- Animals, Antiprotozoal Agents therapeutic use, Cryotherapy, Eosinophilia chemically induced, Exanthema chemically induced, Female, Humans, Intradermal Tests, Leishmaniasis, Cutaneous therapy, Meglumine Antimoniate therapeutic use, Metronidazole therapeutic use, Middle Aged, Antiprotozoal Agents adverse effects, Drug Hypersensitivity Syndrome etiology, Leishmaniasis, Cutaneous drug therapy, Meglumine Antimoniate adverse effects
- Abstract
We report a case of a 64-year-old woman treated with meglumine antimoniate (Glucantime®). On day 20, she developed fever, a pruriginous skin rash and myalgia. The blood tests showed eosinophilia and hepatic cytolysis. The clinico-biological picture improved gradually and the symptoms disappeared 4 weeks after the drug withdrawal. Six weeks later, intradermal tests to Glucantime® were performed and were positive at 48 hour-reading. This clinical picture suggests DRESS induced by meglumine antimoniate. To the best of our knowledge, only one case of meglumine antimoniate-induced DRESS has been reported in the literature and we are the first to report a case confirmed by skin tests.
- Published
- 2018
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