1. Growth response to human growth hormone treatment in children with partial and total growth hormone deficiency.
- Author
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Wit JM, Faber JA, and Van den Brande JL
- Subjects
- Anthropometry, Body Height drug effects, Child, Female, Growth Hormone deficiency, Humans, Male, Thyrotropin deficiency, Growth Disorders drug therapy, Growth Hormone therapeutic use
- Abstract
The growth response during the first and second years of human growth hormone (hGH) treatment was studied in 14 prepubertal children with so-called "partial" GH deficiency (peak GH between 8 and 15 mU/l) and compared to 28 prepubertal children with "total" GH deficiency (peak GH less than 8 mU/l). There was no difference in growth acceleration between children with partial and total GH deficiency, when initial covariables were taken into account. In a stepwise multiple regression analysis initial stature, pre-treatment growth velocity and skinfold thickness were shown to be most related to growth response, but after exclusion of 3 children with a genetic form of total GH deficiency and partial TSH deficiency this relationship was lost. GH levels during provocation tests and auxological criteria have a poor predictive value for growth response to hGH therapy.
- Published
- 1986
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