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Aim: We determined the relationship between circulating advanced glycation end products (AGEs), AGE receptors and homeostatic model assessment for insulin resistance (HOMA-IR) in metabolically healthy obese and normal weight adolescents., Methods: In 2015, we recruited 80 normal weight adolescents and 80 with obesity from schools Leon city, Mexico, and put them into metabolically healthy (HOMA-IR <3.0) and unhealthy (HOMA-IR >3.0) groups. We measured their body mass index (BMI) and carried out detailed blood analyses., Results: We found a higher triglycerides, triglycerides/high-density lipoproteins cholesterol (TG/HDL-C) index, HOMA-IR, tumour necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in the metabolically healthy group and found correlations between HOMA-IR with BMI, the TG/HDL-C index and IL-6 and the TG/HDL-C index and BMI and (TNF-α). There was no correlation between markers of obesity and circulating N-carboxymethyl-lysine (CML) or soluble receptor for advanced glycation end products (sRAGE). Some unhealthy adolescents had higher CML (15.5 ± 2.7 U/mL, p < 0.028) and sRAGE (3123 ± 1364 pg/mL, p < 0.001) than the healthy group., Conclusion: HOMA-IR and the TG/HDL-C index were associated with BMI and inflammation markers. CML and sRAGE were not associated with obesity or inflammation. These parameters were higher in unhealthy obese adolescents., (©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)