1. Association between circulating furin levels, obesity and pro-inflammatory markers in children
- Author
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Lars Jehpsson, Per Swärd, Björn E. Rosengren, and Magnus Karlsson
- Subjects
medicine.medical_specialty ,Adipose tissue ,Overweight ,Body fat percentage ,Body Mass Index ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Absorptiometry, Photon ,030225 pediatrics ,Adipocyte ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Pediatrics, Perinatology, and Child Health ,Obesity ,Child ,Furin ,Adiposity ,biology ,business.industry ,SARS-CoV-2 ,COVID-19 ,General Medicine ,medicine.disease ,Endocrinology ,chemistry ,Pediatrics, Perinatology and Child Health ,Lean body mass ,biology.protein ,medicine.symptom ,business ,Body mass index - Abstract
AIM: To, in children, investigate the associations between serum furin, obesity, overweight, body fat and circulating markers reflecting adipose tissue or systemic inflammation. METHODS: We analysed furin, leptin, adipocyte fatty acid-binding protein, triglycerides, interleukin (IL)-6, IL-8 and C-reactive protein in serum from 166 children in the Pediatric Osteoporosis Prevention (POP) study collected at mean age (SD) 9.9 (0.6) years. Children were classified as low-to-normal weight, overweight or obese. Total body fat mass (kg), trunk fat mass (kg) and total body lean mass (kg) were measured by dual-energy X-ray absorptiometry. Body fat percentage (%) was calculated. RESULTS: We found that circulating furin levels were higher in children with obesity and overweight compared with children with low-to-normal weight (p
- Published
- 2021