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Aim: Investigate potential long- term cohort influences on health-related quality of life (HRQoL) in adults born extremely preterm (EP) during the 1980-90s, in view of advancements in neonatal care within that timeframe. Methods: Two cohorts of EP-born adults (82-85 cohort and 91-92 cohort) enrolling matched term controls, were compared. Participants were assessed at 18 years and again in their mid-twenties using the Child Health Questionnaire Children Form- 87 (CHQ-CF87) and the Short Form Health Survey (SF-36). Results: At 18 years, 77 (90%) EP- born and 75 (93%) term controls had data, followed by 67 (78%) EP-born and 66 (82%) term controls in their mid-twenties. At 18 years, there were no differences across the birth decades, and EP-born and term-born reported relatively similar HRQoL scores. In the mid- twenties, birth decade did also not significantly impact HRQoL scores, although the EP--born 82-85 cohort scored numerically poorer than the 91-92 cohort in three domains. Term controls scored similarly across birth decade in all domains. Regarding influence from neonatal factors, postnatal corticosteroids had a negative impact in some domains. Conclusion: No significant differences in HRQoL were observed between EP-born adults from the 82-85 cohort versus the 91-92 cohort, although the EP- born 82-85 cohort tended to score poorer in their mid-twenties. [ABSTRACT FROM AUTHOR]

Aim Methods Results Conclusion Advances in perinatal medicine from 1980 to 2000 improved survival in extremely preterm (EP) neonates. Long‐term effects of these developments remain unclear, and we aimed to investigate potential cohort effects on adult lung function.Three 18‐year‐old population‐based cohorts born at ≤28 weeks gestation or with birthweight ≤1000 g during 1982–85, 1991–92 and 1999–2000 and term‐controls underwent spirometry, body plethysmography, and tests of lung diffusing capacity, bronchodilator reversibility, and airway hyperresponsiveness. We used Welch's t‐tests to compare term‐ with EP‐born as a group and split by bronchopulmonary dysplasia (BPD), and regression models to test group/cohort interactions.In all EP‐born cohorts, z‐scores for FEV1, FEV1/FVC, FEF25%–75%, DLCO and KCO were reduced compared with term‐born. For the 82–85, 91–92 and 99–00 cohorts, deficits for z‐FEV1 and z‐DLCO were 1.23 and 0.53; 0.68 and 0.92; and 0.51 and 0.57, respectively (p ≤0.01 for all). Cohort analyses showed stable lung function across the three cohorts overall, but improvements across cohorts for the BPD subgroups in z‐FEV1, z‐FEV1/FVC, and z‐FEF25%–75%.Adults born EP across three formative decades of neonatal care had stable lung function overall, with notable improvements in BPD subgroups across cohorts. [ABSTRACT FROM AUTHOR]