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Objective: We present our outcome in the treatment of 125 patients with malignant glottic lesions between 1992 and 2003 in a retrospective study., Patient and Methods: We analyze 125 cases of patients, with previously untreated carcinoma of the larynx with histological diagnosis, treated with Transoral Laser Microresection. We will pay special attention to those tumors involving the Anterior Commissure. We will also analyze several parameters related to the post and intraoperatory histopathological report, in order to decide adjuvant therapies. We will also analyze the technique indications, complications, hospital length of stay, oncologic and functional outcomes, survival and follow up of recurrences., Outcomes and Conclusion: Transoral laser microresection is an effective and functional preserving procedure, and nowadays the base of the treatment of early glottic carcinoma. Anterior Commissure involvement is a prognostic factor. Sometimes complementary therapies are needed based on by the histopathological report.