26 results on '"Liberati, A"'
Search Results
2. Role of prenatal magnetic resonance imaging in fetuses with isolated agenesis of corpus callosum in the era of fetal neurosonography: A systematic review and meta‐analysis
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Sileo, Filomena Giulia, primary, Di Mascio, Daniele, additional, Rizzo, Giuseppe, additional, Caulo, Massimo, additional, Manganaro, Lucia, additional, Bertucci, Emma, additional, Masmejan, Sophie, additional, Liberati, Marco, additional, D’Amico, Alice, additional, Nappi, Luigi, additional, Buca, Danilo, additional, Van Mieghem, Tim, additional, Khalil, Asma, additional, and D’Antonio, Francesco, additional
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- 2020
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3. Reproductive outcome after cesarean scar pregnancy: A systematic review and meta‐analysis
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Morlando, Maddalena, primary, Buca, Danilo, additional, Timor‐Tritsch, Ilan, additional, Cali, Giuseppe, additional, Palacios‐Jaraquemada, Jose, additional, Monteagudo, Ana, additional, Khalil, Asma, additional, Cennamo, Carmen, additional, La Manna, Viviana, additional, Liberati, Marco, additional, D’Amico, Alice, additional, Nappi, Luigi, additional, Colacurci, Nicola, additional, and D’Antonio, Francesco, additional
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- 2020
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4. Diagnostic accuracy of Doppler ultrasound in predicting perinatal outcome in pregnancies at term: A prospective longitudinal study
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D'Antonio, Francesco, primary, Rizzo, Giuseppe, additional, Gustapane, Sarah, additional, Buca, Danilo, additional, Flacco, Maria Elena, additional, Martellucci, Cecilia, additional, Manzoli, Lamberto, additional, Makatsariya, Alexander, additional, Nappi, Luigi, additional, Pagani, Giorgio, additional, and Liberati, Marco, additional
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- 2019
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5. Beat-to-beat estimate of fetal cardiac time intervals using magnetocardiography: longitudinal charts of normality ranges and individual trends
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Comani, Silvia, Liberati, Marco, Mantini, Dante, Merlino, Biagio, Alleva, Giovanna, Gabriele, Elisabetta, Di Luzio, Silvano, and Romani, Gian Luca
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- 2005
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6. Outcome of isolated fetal talipes: A systematic review and meta‐analysis
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Di Mascio, Daniele, primary, Buca, Danilo, additional, Khalil, Asma, additional, Rizzo, Giuseppe, additional, Makatsariya, Alexander, additional, Sileo, Filomena, additional, Liberati, Marco, additional, Benedetti Panici, Pierluigi, additional, Acharya, Ganesh, additional, and D'Antonio, Francesco, additional
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- 2019
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7. Birthweight discordance and neonatal morbidity in twin pregnancies: A systematic review and meta‐analysis
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Di Mascio, Daniele, primary, Acharya, Ganesh, additional, Khalil, Asma, additional, Odibo, Anthony, additional, Prefumo, Federico, additional, Liberati, Marco, additional, Buca, Danilo, additional, Manzoli, Lamberto, additional, Flacco, Maria E., additional, Brunelli, Roberto, additional, Benedetti Panici, Pierluigi, additional, and D'Antonio, Francesco, additional
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- 2019
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8. Role of prenatal magnetic resonance imaging in fetuses with isolated agenesis of corpus callosum in the era of fetal neurosonography: A systematic review and meta‐analysis.
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Sileo, Filomena Giulia, Di Mascio, Daniele, Rizzo, Giuseppe, Caulo, Massimo, Manganaro, Lucia, Bertucci, Emma, Masmejan, Sophie, Liberati, Marco, D'Amico, Alice, Nappi, Luigi, Buca, Danilo, Van Mieghem, Tim, Khalil, Asma, and D'Antonio, Francesco
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FETAL MRI ,AGENESIS of corpus callosum ,FETAL abnormalities ,PRENATAL diagnosis ,GESTATIONAL age - Abstract
Introduction: Corpus callosum agenesis (ACC) is frequently diagnosed during fetal life; its prognosis depends also on additional anomalies. The additional value of fetal magnetic resonance imaging (MRI) in fetuses with "isolated" complete (cACC) and partial (pACC) agenesis of the corpus callosum on ultrasound is still debated. Material and methods: We performed a systematic literature review and meta‐analysis including fetuses with a prenatal diagnosis of cACC and pACC without associated structural anomalies on ultrasound, undergoing fetal MRI. The primary outcome was the rate of additional anomalies detected at fetal MRI. Further analyses assessed the effect of type of ultrasound assessment (neurosonography vs standard axial assessment), gestational age at fetal MRI and rate of postnatally detected brain anomalies. Random‐effect meta‐analyses of proportions were used to analyze the data. Results: Fourteen studies (798 fetuses) were included. In cases with isolated cACC, 10.9% (95% CI 4.1‐20.6) and 4.3% (95% CI 1.4‐8.8) additional anomalies were detected by fetal MRI and postnatally, respectively. Stratifying according to the type of ultrasound assessment, the rate of associated anomalies detected only on fetal MRI was 5.7% (95% CI 0.5‐16.0) with dedicated neurosonography and 18.5% (95% CI 7.8‐32.4) with a standard axial assessment. In fetuses with isolated pACC, 13.4% (95% CI 4.0‐27.0) and 16.2% (95% CI 5.9‐30.3) additional anomalies were detected by fetal MRI or postnatally, respectively. Stratifying according to the type of ultrasound assessment, the rate of associated anomalies detected only on fetal MRI was 11.4% (95% CI 2.7‐25.0) when dedicated neurosonography was performed. Cortical and posterior fossa anomalies represented the most common anomalies missed at ultrasound with both cACC and pACC. Due to the very small number of included cases, stratification according to early (<24 weeks of gestation) and late (>24 weeks) fetal MRI could not be done for either cACC or pACC. Conclusions: The rate of associated anomalies detected exclusively at fetal MRI in isolated ACC undergoing neurosonography is lower than previously reported. Cortical and posterior fossa anomalies are among the most common anomalies detected exclusively at MRI, thus confirming the crucial role of fetal MRI in determining the prognosis of these fetuses. However, some anomalies still go undetected prenatally and this should be stressed during parental counseling. [ABSTRACT FROM AUTHOR]
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- 2021
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9. Diagnostic accuracy of ultrasound in detecting the severity of abnormally invasive placentation: a systematic review and meta-analysis
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Giovanni Scambia, Marco Liberati, Ilan-Timor Trisch, Francesco Fanfani, Giorgio Pagani, Alessandra Familiari, Ganesh Acharya, Francesco D'Antonio, Giuseppe Calì, Danilo Buca, Lamberto Manzoli, José M. Palacios-Jaraquemada, and Maria Elena Flacco
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medicine.medical_specialty ,Placenta accreta ,Placenta Percreta ,Placenta ,abnormally invasive placenta ,increta ,percreta ,placenta accreta ,prenatal diagnosis ,ultrasound ,Socio-culturale ,Diagnostic accuracy ,Prenatal diagnosis ,Placenta Accreta ,Sensitivity and Specificity ,Ultrasonography, Prenatal ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Vascularity ,Pregnancy ,parasitic diseases ,medicine ,Humans ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,Ultrasound ,Placentation ,Obstetrics and Gynecology ,General Medicine ,Hypervascularity ,medicine.disease ,medicine.anatomical_structure ,Meta-analysis ,Myometrium ,Female ,Radiology ,medicine.symptom ,business ,Placenta Increta - Abstract
Introduction Our objective was to elucidate the overall diagnostic accuracy of ultrasound in detecting the severity of abnormally invasive placentation (AIP). Material and methods Medline, Embase, CINAHL and The Cochrane databases were searched. The ultrasound signs explored were: loss of hypoechoic (clear) zone in the placental–uterine interface, placental lacunae, bladder wall interruption, myometrial thinning, focal exophitic mass, placental lacunar flow, subplacental vascularity, and uterovesical hypervascularity. Results Twenty studies (3209 pregnancies) were included. Ultrasound had an overall good diagnostic accuracy in identifying the depth of placental invasion with sensitivities of 90.6%, 93.0%, 89.5%, and 81.2% for placenta accreta, increta, accreta/increta, and percreta, respectively; the corresponding specificities were 97.1%, 98.4%, 94.7%, and 98.9%. Placental lacunae had sensitivities of 74.8%, 88.6%, and 76.3% for the detection of placenta accreta, increta, and percreta, respectively. Sensitivity and specificity of loss of the clear zone in identifying placenta accreta were 74.9% and 92.0%, whereas the corresponding figures for placenta increta and percreta were 91.6% and 76.9%, and 88.1% and 71.1%. Lacunar flow had sensitivities of 81.2%, 84.3%, and 45.2% for the detection of placenta accreta, increta, and percreta respectively; the corresponding figures for specificity were 84.0%, 79.7%, and 75.3%. Sensitivity of uterovesical hypervascularity was low for the detection of placenta accreta (12.3%) but high for placenta increta (94.4%) and percreta (86.2%); the corresponding figures for specificity were 90.8%, 88.0% and 88.2%, respectively. Conclusions Ultrasound has an overall good diagnostic accuracy in recognizing the depth and the topography of placental invasion.
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- 2017
10. Diagnostic accuracy of Doppler ultrasound in predicting perinatal outcome in pregnancies at term: A prospective longitudinal study.
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D'Antonio, Francesco, Rizzo, Giuseppe, Gustapane, Sarah, Buca, Danilo, Flacco, Maria Elena, Martellucci, Cecilia, Manzoli, Lamberto, Makatsariya, Alexander, Nappi, Luigi, Pagani, Giorgio, and Liberati, Marco
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DOPPLER ultrasonography ,UTERINE artery ,LONGITUDINAL method ,LOGISTIC regression analysis ,PREGNANCY - Abstract
Introduction: To explore the strength of association and the diagnostic accuracy of umbilical (UA), middle cerebral (MCA), uterine arteries pulsatility index (PI) and the cerebroplacental ratio in predicting an adverse outcome when applied to singleton pregnancies at term.Material and Methods: Prospective study carried out in a dedicated research ultrasound clinic. Attended clinicians were blinded to Doppler findings. Inclusion criteria were consecutive singleton pregnancies between 36+0 and 37+6 weeks of gestation. The primary outcome was a composite score of adverse perinatal outcome. Logistic regression and ROC curve analyses were used to analyze the data.Results: In all, 600 consecutive singleton pregnancies from 36 weeks of gestation were included in the study. Mean MCA PI (1.1 ± 0.2 vs 1.5 ± 0.4, P < 0.001) and cerebroplacental ratio (1.4 ± 0.4 vs 1.9 ± 0.6, P < 0.001) were lower, whereas uterine arteries PI (0.8 ±0.2 vs 0.7 ±0.3, P = 0.001) was higher in pregnancies experiencing than in those not experiencing composite adverse outcome. Conversely, there was no difference in either UA PI (P = 0.399) or estimated fetal weight centile (P = 0.712) between the two groups, but AC centile was lower in fetuses experiencing composite adverse outcome (45.4 vs 53.2, P = 0.040). At logistic regression analysis, MCA PI (odds ratio [OR] 0.1, 95% CI 0.01-.2, P = 0.001), uterine arteries PI (OR 1.4, 95% CI 1.2-1.6, P = 0.001), abdominal circumference centile (OR 1.12, 95% CI 1.1-1.4, P = 0.001) and gestational age at birth (OR 1.6, 95% CI 1.2-2.1, P = 0.004) were independently associated with composite adverse outcome. Despite this, the diagnostic accuracy of Doppler in predicting adverse pregnancy outcome at term was poor.Conclusions: MCA PI and cerebroplacental ratio are associated with adverse perinatal outcome at term. However, their predictive accuracy for perinatal compromise is poor, and thus their use as standalone screening test for adverse perinatal outcome in singleton pregnancies at term is not supported. [ABSTRACT FROM AUTHOR]- Published
- 2020
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11. Diagnostic accuracy of magnetic resonance imaging in detecting the severity of abnormal invasive placenta: a systematic review and meta‐analysis
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Familiari, Alessandra, primary, Liberati, Marco, additional, Lim, Philip, additional, Pagani, Giorgio, additional, Cali, Giuseppe, additional, Buca, Danilo, additional, Manzoli, Lamberto, additional, Flacco, Maria E., additional, Scambia, Giovanni, additional, and D'antonio, Francesco, additional
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- 2017
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12. Diagnostic accuracy of ultrasound in detecting the severity of abnormally invasive placentation: a systematic review and meta‐analysis
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Pagani, Giorgio, primary, Cali, Giuseppe, additional, Acharya, Ganesh, additional, Trisch, Ilan‐Timor, additional, Palacios‐Jaraquemada, Jose, additional, Familiari, Alessandra, additional, Buca, Danilo, additional, Manzoli, Lamberto, additional, Flacco, Maria E., additional, Fanfani, Francesco, additional, Liberati, Marco, additional, Scambia, Giovanni, additional, and D'antonio, Francesco, additional
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- 2017
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13. The effect of antenatal steroid administration on the fetal response to vibroacoustic stimulation
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Sigi Rotmensch, Oscar Sadan, Marek Glezerman, Marco Liberati, and Claudio Celentano
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Fetus ,Startle response ,medicine.diagnostic_test ,medicine.drug_class ,business.industry ,Obstetrics and Gynecology ,Gestational age ,General Medicine ,Vibroacoustic stimulation ,Antenatal steroid ,Anesthesia ,Fetal movement ,medicine ,Corticosteroid ,Betamethasone ,business ,medicine.drug - Abstract
Background. Betamethasone transiently suppresses multiple fetal biophysical activities, including breathing movements, limb and trunk movements, heart rate variability, and heart rate accelerations. Unnecessary iatrogenic delivery of preterm fetuses due to the false diagnosis of fetal compromise has been described in this setting. The sonographically observed startle response of the fetus to vibroacoustic stimulation has been described as another modality to provide reassurance about fetal well-being. It is unknown, however, whether the startle response is also suppressed by betamethasone. The purpose of this study was to examine the effect of betamethasone on this biophysical parameter. Methods. A prospective cohort study. Vibroacoustic stimulation was applied to the maternal abdomen and fetal movement responses were sonographically observed prior to (0 hours), 48 hours after, and 96 hours after betamethasone administration. We recorded the presence or absence of the fetal startle response, and, if a response was present, graded semi-quantitatively the intensity of the movements (vigorous versus sluggish). Results. Twenty-two of 26 fetuses (84.6%) displayed a vigorous vibroacoustic startle response prior to betamethasone administration, in comparison to three of 26 fetuses (11.5%) at 48 hours after exposure (p
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- 1999
14. The effect of betamethasone on fetal biophysical activities and Doppler velocimetry of umbilical and middle cerebral arteries
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Claudio Celentano, Itai Bar-Hava, Z. Efrat, Zion Ben-Rafael, Gil Moravski, Avraham Golan, Mihal Kovo, Marco Liberati, and Siegfried Rotmensch
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Biophysical profile ,Fetus ,business.industry ,Cerebral arteries ,Obstetrics and Gynecology ,Umbilical artery ,General Medicine ,Antenatal steroid ,Cerebral circulation ,medicine.artery ,Anesthesia ,Middle cerebral artery ,Medicine ,Betamethasone ,business ,medicine.drug - Abstract
Objective. Preliminary reports suggest that antenatal steroid administration may confound the assessment of fetal well-being by suppressing biophysical activities, consequently drug-induced effects could prompt unwarranted delivery of premature fetuses. The purpose of this study was to examine the effect of antenatal betamethasone administration on fetal biophysical activities and Doppler flow indices of the umbilical and middle cerebral circulation. Methods. Forty women at risk of premature delivery between 27-32 weeks gestation (mean 30.2 weeks) received two consecutive doses of intramuscular betamethasone, 24 hours apart. Ultrasonographic observations of fetal behavior for 30 minute periods and Doppler examination of the umbilical and cerebral arteries were performed prior to (0 hours), 48 hours after, and 96 hours after administration of the first dose. To account for fetal circadian rhythms and maternal prandial status, all examinations were carefully timed and performed between 1-4 pm. Analysis of Variance, chi-square test and Fisher's Exact test were used for statistical analysis, as appropriate. Results. Nine patients were excluded from analysis due to delivery prior to completion of all examinations. Number of breathing episodes as well as total breathing time at 48 hours decreased by 83.0% (p
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- 1999
15. The effect of betamethasone and dexamethasone on fetal heart rate patterns and biophysical activities, A prospective randomized trial
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Claudio Celentano, Siegfried Rotmensch, U. Bellati, Zion Ben-Rafael, Tal H. Vishne, and Marco Liberati
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Fetus ,Pregnancy ,business.industry ,medicine.drug_class ,Obstetrics and Gynecology ,Gestational age ,General Medicine ,medicine.disease ,Anesthesia ,Heart rate ,Breathing ,Medicine ,Corticosteroid ,Betamethasone ,business ,Dexamethasone ,medicine.drug - Abstract
UNLABELLED BACKGROUND; Contradictory findings on the effect of betamethasone versus dexamethasone on antenatal tests of fetal well-being have been reported. The purpose of this study was to compare the effects of these steroid compounds on fetal heart rate patterns and biophysical activities in a prospective. randomized trial. STUDY DESIGN Forty-six pregnant women (gestational age range 27-34 weeks) at risk for preterm delivery were randomized to receive betamethasone or dexamethasone for enhancement of fetal lung maturity. Fetal heart rate was recorded for 60 minutes and analyzed with the Sonicaid System 8000 before (0 hours), and 48 hours and 96 hours after steroid administration. Subsequently, fetal limb, body and breathing movements were sonographically observed and quantified for 30 minutes. To account for fetal circadian rhythms, all examinations were performed between 1 p.m. and 5 p.m., at least one hour after maternal meals. RESULTS Fetal heart rate accelerations (p
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- 1999
16. The effect of betamethasone and dexamethasone on fetal heart rate patterns and biophysical activities, A prospective randomized trial
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Siegfried Rotmensch, Marco Liberati, TalH. Vishne, Claudio Celentano, Zion Ben-Rafael, and Umberto Bellati
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Adult ,Pregnancy ,Respiration ,Humans ,Obstetrics and Gynecology ,Female ,Prospective Studies ,General Medicine ,Heart Rate, Fetal ,Betamethasone ,Fetal Movement ,Glucocorticoids ,Dexamethasone - Abstract
BACKGROUND; Contradictory findings on the effect of betamethasone versus dexamethasone on antenatal tests of fetal well-being have been reported. The purpose of this study was to compare the effects of these steroid compounds on fetal heart rate patterns and biophysical activities in a prospective. randomized trial.Forty-six pregnant women (gestational age range 27-34 weeks) at risk for preterm delivery were randomized to receive betamethasone or dexamethasone for enhancement of fetal lung maturity. Fetal heart rate was recorded for 60 minutes and analyzed with the Sonicaid System 8000 before (0 hours), and 48 hours and 96 hours after steroid administration. Subsequently, fetal limb, body and breathing movements were sonographically observed and quantified for 30 minutes. To account for fetal circadian rhythms, all examinations were performed between 1 p.m. and 5 p.m., at least one hour after maternal meals.Fetal heart rate accelerations (p0.001; p0.01), short-term variation (p0.0001; p0.05), long-term variation (p0.01; p=NS), duration of high episodes (p0.001; p0.05), total movement count (p0.001; p0.05), and duration of breathing time (p0.0001; p0.0001) were substantially reduced 48 h after betamethasone and dexamethasone administration, respectively, with percent reduction being larger for the betamethasone group, except for breathing movements (p0.05; p0.001; p0.001; p0.005; p0.05; p=NS; respectively). In 68.2%( and 45.5% of fetuses, less than 30 seconds of continuous breathing movements were found in the betamethasone and dexamethasone groups, respectively. In 71.8% and 12.5%, of fetuses, respectively, less than 2 body/limb movements were observed. Therefore five and two fetuses in the betamethasone and dexamethasone study group, respectively, had both nonreactive fetal heart rate monitors for 60 minutes and biophysical profiles ofor =4/10. All parameters returned to baseline values at 96 h. Baseline fetal heart rate and numbers of decelerations remained unchanged (p=NS).Both betamethasone and dexamethasone induce a profound, albeit transient, suppression of fetal heart rate characteristics and biophysical activities in the preterm fetus. However, the effect of betamethasone is more pronounced. Awareness of these phenomena might prevent unwarranted iatrogenic delivery of preterm fetuses.
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- 1999
17. The effect of betamethasone on fetal biophysical activities and Doppler velocimetry of umbilical and middle cerebral arteries
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Siegfried Rotmensch, Marco Liberati, Claudio Celentano, Zeev Efrat, Itai Bar-Hava, Mihal Kovo, Avraham Golan, Gil Moravski, and Zion Ben-Rafael
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Adult ,Middle Cerebral Artery ,Time Factors ,Pregnancy Trimester, Third ,Respiration ,Obstetrics and Gynecology ,General Medicine ,Betamethasone ,Ultrasonography, Prenatal ,Umbilical Arteries ,Fetus ,Pregnancy ,Laser-Doppler Flowmetry ,Humans ,Female ,Ultrasonography, Doppler, Color ,Fetal Movement ,Glucocorticoids ,Maternal-Fetal Exchange ,Blood Flow Velocity - Abstract
Preliminary reports suggest that antenatal steroid administration may confound the assessment of fetal well-being by suppressing biophysical activities, consequently drug-induced effects could prompt unwarranted delivery of premature fetuses. The purpose of this study was to examine the effect of antenatal betamethasone administration on fetal biophysical activities and Doppler flow indices of the umbilical and middle cerebral circulation.Forty women at risk of premature delivery between 27-32 weeks gestation (mean 30.2 weeks) received two consecutive doses of intramuscular betamethasone, 24 hours apart. Ultrasonographic observations of fetal behavior for 30 minute periods and Doppler examination of the umbilical and cerebral arteries were performed prior to (0 hours), 48 hours after, and 96 hours after administration of the first dose. To account for fetal circadian rhythms and maternal prandial status, all examinations were carefully timed and performed between 1-4 pm. Analysis of Variance, chi-square test and Fisher's Exact test were used for statistical analysis, as appropriate.Nine patients were excluded from analysis due to delivery prior to completion of all examinations. Number of breathing episodes as well as total breathing time at 48 hours decreased by 83.0% (p0.01) and 90.4% (p0.01), respectively, at 48 hours in comparison to baseline. Fetal limb and trunk movements decreased by 53.2% (p0.01) and 48.6% (p0.01), respectively. Amniotic fluid volume and fetal tone were normal in all patients. At 48 hours, 14 of 31 fetuses and 4 of 31 fetuses had a biophysical profile score of 6/8 and 4/8, respectively, in comparison to 0 of 31 and 0 of 31 at 0 hours (p0.05 and p0.001, respectively). All parameters returned to baseline values at 96 h. Pulsatility indices of umbilical and middle cerebral arteries remained unchanged at 48 hours and 96 hours (p=NS).Betamethasone induces a profound, albeit transient, suppression of fetal breathing, limb and trunk movements, resulting in decreased biophysical profile scores. Awareness of this drug-induced effect might prevent unnecessary iatrogenic delivery of preterm fetuses.
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- 1999
18. Diagnostic accuracy of magnetic resonance imaging in detecting the severity of abnormal invasive placenta: a systematic review and meta-analysis.
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Familiari, Alessandra, Liberati, Marco, Lim, Philip, Pagani, Giorgio, Cali, Giuseppe, Buca, Danilo, Manzoli, Lamberto, Flacco, Maria E., Scambia, Giovanni, D'antonio, Francesco, and D'antonio, Francesco
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MAGNETIC resonance imaging , *PREGNANCY complications , *PLACENTA , *CERVICAL cancer , *TRANSVAGINAL ultrasonography , *META-analysis , *PLACENTA diseases , *PRENATAL diagnosis , *SYSTEMATIC reviews , *LOGISTIC regression analysis - Abstract
Introduction: Accurate prenatal diagnosis of abnormally invasive placenta (AIP) is fundamental because it significantly reduces maternal morbidities.Material and Methods: Medline, Embase, CINAHL and the Cochrane databases were searched. The primary aim of the present review was to elucidate the diagnostic accuracy of prenatal magnetic resonance imaging (MRI) in recognizing the severity of AIP, defined as the depth and topography of invasion. The secondary aim was to ascertain the strength of association between each MRI sign and the depth of placental invasion and to test their individual predictive accuracy in detecting such invasion. Inclusion criteria were studies on women who had prenatal MRI for ultrasound suspicion or the presence of clinical risk factors for AIP. Estimates of sensitivity, specificity, positive and negative likelihood ratios and diagnostic odds ratio were calculated using the hierarchical summary receiver characteristics curve model, and individual data random-effect logistic regression was used to calculate OR.Results: Twenty studies (1080 pregnancies undergoing MRI mainly for the ultrasound suspicion of AIP) were included. MRI showed a sensitivity of 94.4% [95% confidence interval (CI) 15.8-99.9], 100% (95% CI 75.3-100) and 86.5% (95% CI 74.2-94.4) for detection of placenta accreta, increta and percreta, respectively; the corresponding values for specificity were 98.8% (95% CI 70.7-100), 97.3% (95% CI 93.3-99.3), 96.8% (95% CI 93.5-98.7). MRI identified 100% of cases with S1 and 100% of those with S2 invasion confirmed at surgery. Among the different MRI signs, intra-placental dark bands showed the best sensitivity for the detection of placenta accreta, increta and percreta; as well as abnormal intra-placental vascularity, uterine bulging was associated with a higher risk of increta and percreta, exophitic mass and bladder tenting with placenta percreta.Conclusion: Prenatal MRI has an excellent diagnostic accuracy in identifying the depth and the topography of placental invasion. However, these findings come mainly from studies in which MRI was performed as a secondary imaging tool in women already screened for AIP on ultrasound and might not reflect its actual diagnostic performance in detecting the severity of these disorders. [ABSTRACT FROM AUTHOR]- Published
- 2018
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19. Beat-to-beat estimate of fetal cardiac time intervals using magnetocardiography: longitudinal charts of normality ranges and individual trends
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Silvia, Comani, Marco, Liberati, Dante, Mantini, Biagio, Merlino, Giovanna, Alleva, Elisabetta, Gabriele, Silvano, Di Luzio, and Gian Luca, Romani
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Adult ,Cardiotocography ,Predictive Value of Tests ,Pregnancy ,Pregnancy Trimester, Second ,Pregnancy Trimester, Third ,Humans ,Female ,Longitudinal Studies ,Heart Rate, Fetal - Abstract
Fetal magnetocardiography (fMCG) records fetal cardiac electro-physiological activity during the second half of gestation. We aimed at assessing normality values, related variability, and trends of fetal cardiac time intervals (fCTI) evaluated longitudinally from beat-to-beat fMCG analysis in uncomplicated pregnancies.The fMCG were recorded with multi-channel system in shielded room. FCTI were estimated on more than 2600 fetal cardiac cycles from 51 fMCG data sets of uncomplicated pregnancies. Independent component analysis (ICA) allowed reconstructing reliable fetal signals for beat-to-beat identification of fCTI (RR, P wave, PQ, PR, QT, QTc, QRS, ST, and T wave); intra-individual variability analysis and trends were calculated; reference longitudinal charts accounted for intra- and inter-individual variations and were compared with figures estimated on averaged signals.For each data set, fCTI were calculated beat-to-beat on rhythm strips of more than 50 beats (95% overall detection rate). FCTI values, variability, and trends were in good agreement with available reference figures; intervals related to P and T waves were, respectively, underestimated and overestimated with respect to those estimated on averaged signals or obtained by other research groups. Errors were reduced and individual trends could be drawn.ICA permitted the reconstruction of reliable time course of fetal cardiac signals and the beat-to-beat calculation of time intervals, and normality ranges, with smaller errors with respect to previous studies. The retrieval of fetal traces with clear morphology and the longitudinal character of the study allowed estimating individual trends and beat-to-beat characterization, impossible with cross-sectional studies on averaged beats.
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- 2005
20. Steroid hormones and gonadotropins in a case of ovarian endometriosis associated with virilization
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S. Ricci, L. Olleja, D. Mango, Marco Liberati, M. T. Benedetto, F. de Cicco Nardone, E. Menini, and P. Manna
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medicine.medical_specialty ,Endometriosis ,Ovary ,Functioning tumor ,Internal medicine ,medicine ,Humans ,Receptor ,Gonadal Steroid Hormones ,Testosterone ,Ovarian Neoplasms ,business.industry ,Virilization ,Hyperandrogenism ,Obstetrics and Gynecology ,General Medicine ,Middle Aged ,medicine.disease ,Virilism ,Endocrinology ,medicine.anatomical_structure ,Gonadotropins, Pituitary ,Ovarian Endometriosis ,Female ,medicine.symptom ,business ,Hormone - Abstract
The clinical course, the hormone secretion, the testosterone receptors and the enzymatic activities related to androgen metabolism in a 56-year-old postmenopausal woman with a history of virilization and ovarian endometrioma are reported. Unexpectedly, at the time of examination, no evidence of biochemical hyperandrogenism was obtained. The uncommon association of virilization and ovarian endometrioma simulating a functioning tumor of the ovary is discussed.
- Published
- 1992
21. The effect of antenatal steroid administration on the fetal response to vibroacoustic stimulation
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Rotmensch, Sigi, primary, Celentano, Claudio, additional, Liberati, Marco, additional, Sadan, Oscar, additional, and Glezerman, Marek, additional
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- 1999
- Full Text
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22. The effect of betamethasone on fetal biophysical activities and Doppler velocimetry of umbilical and middle cerebral arteries
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Rotmensch, Siegfried, primary, Liberati, Marco, additional, Celentano, Claudio, additional, Efrat, Zeev, additional, Bar-Hava, Itai, additional, Kovo, Mihal, additional, Golan, Avraham, additional, Moravski, Gil, additional, and Ben-Rafael, Zion, additional
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- 1999
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23. The effect of betamethasone and dexamethasone on fetal heart rate patterns and biophysical activities, A prospective randomized trial
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Rotmensch, Siegfried, primary, Liberati, Marco, additional, Vishne, Tal H., additional, Celentano, Claudio, additional, Ben‐Rafael, Zion, additional, and Bellati, Umberto, additional
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- 1999
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24. Steroid hormones and gonadotropins in a case of ovarian endometriosis associated with virilization
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Mango, D., primary, Manna, P., additional, Liberati, M., additional, Benedetto, M. T., additional, Ricci, S., additional, Olleja, L., additional, de Cicco Nardone, F., additional, and Menini, E., additional
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- 1992
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25. Response to Human Chorionic Gonadotropin in Patients with Ovarian Tumors
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T. Iacona, Salvatore Mancuso, E. Tartaglia, P. Manna, P. Scirpa, M. Liberati, S. Ricci, and D. Mango
- Subjects
endocrine system ,medicine.medical_specialty ,Estrone ,Chorionic Gonadotropin ,Human chorionic gonadotropin ,Ovarian tumor ,chemistry.chemical_compound ,In vivo ,Internal medicine ,Humans ,Medicine ,Testosterone ,Androstenedione ,Aged ,Ovarian Neoplasms ,Estradiol ,business.industry ,Obstetrics and Gynecology ,General Medicine ,Middle Aged ,medicine.disease ,Menopause ,Endocrinology ,chemistry ,Female ,business ,Ovarian cancer ,hormones, hormone substitutes, and hormone antagonists - Abstract
The results of hCG stimulation on peripheral levels of androstenedione (A), testosterone (T) and estrone (E1) were examined in 14 patients with ovarian tumors and in 9 tumor-free subjects, after the menopause. Following hCG injection, 9 postmenopausal patients with ovarian tumors showed a significant rise in A peripheral levels. The responsive subjects generally had significant increases in A baseline levels, too. The remaining 5 subjects with advanced or poorly differentiated ovarian cancer with no stroma were not responsive to hCG. Moreover, in the tumor group, 7 subjects had increased baseline T and/or E1 and in 3 of them an increase of these steroids was observed following hCG. In the absence of ovarian tumor, no subject in the control group was responsive to hCG administration. The results of the present investigation seem to confirm the in vivo responsiveness to hCG of ovarian tumors.
- Published
- 1988
26. Response to Human Chorionic Gonadotropin in Patients with Ovarian Tumors
- Author
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Scirpa, P., Mango, D., Liberati, M., Manna, P., Tartaglia, E., Ricci, S., Iacona, T., and Mancuso, S.
- Abstract
The results of hCG stimulation on peripheral levels of androstenedione (A), testosterone (T) and estrone (El) were examined in 14 patients with ovarian tumors and in 9 tumor-free subjects, after the menopause. Following hCG injection, 9 postmenopausal patients with ovarian tumors showed a significant rise in A peripheral levels. The responsive subjects generally had significant increases in A baseline levels, too. The remaining 5 subjects with advanced or poorly differentiated ovarian cancer with no stroma were not responsive to hCG. Moreover, in the tumor group, 7 subjects had increased baseline T and/or El and in 3 of them an increase of these steroids was observed following hCG. In the absence of ovarian tumor, no subject in the control group was responsive to hCG administration. The results of the present investigation seem to confirm the in vivo responsiveness to hCG of ovarian tumors.
- Published
- 1988
- Full Text
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