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Your search keyword '"Uro-Coste, Emmanuelle"' showing total 13 results
Start Over Author "Uro-Coste, Emmanuelle" Journal acta neuropathologica communications
13 results on '"Uro-Coste, Emmanuelle"'

1. CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas

Author

Tauziède-Espariat, Arnault, Nicaise, Yvan, Sievers, Philipp, Sahm, Felix, von Deimling, Andreas, Guillemot, Delphine, Pierron, Gaëlle, Duchesne, Mathilde, Edjlali, Myriam, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Roux, Alexandre, Dezamis, Edouard, Hasty, Lauren, Lhermitte, Benoît, Hirsch, Edouard, Hirsch, Maria Paola Valenti, Ardellier, François-Daniel, Karnoub, Mélodie-Anne, Csanyi, Marie, Maurage, Claude-Alain, Mokhtari, Karima, Bielle, Franck, Rigau, Valérie, Roujeau, Thomas, Abad, Marine, Klein, Sébastien, Bernier, Michèle, Horodyckid, Catherine, Adam, Clovis, Brandal, Petter, Niehusmann, Pitt, Vannod-Michel, Quentin, Provost, Corentin, de Champfleur, Nicolas Menjot, Nichelli, Lucia, Métais, Alice, Mariet, Cassandra, Chrétien, Fabrice, Blauwblomme, Thomas, Beccaria, Kévin, Pallud, Johan, Puget, Stéphanie, Uro-Coste, Emmanuelle, and Varlet, Pascale

Published
2024
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3. CNS neuroblastoma, FOXR2-activated and its mimics: a relevant panel approach for work-up and accurate diagnosis of this rare neoplasm

Author

Tauziède-Espariat, Arnault, Figarella-Branger, Dominique, Métais, Alice, Uro-Coste, Emmanuelle, Maurage, Claude-Alain, Lhermitte, Benoît, Aline-Fardin, Aude, Hasty, Lauren, Vasiljevic, Alexandre, Chiforeanu, Dan, Chotard, Guillaume, Adle-Biassette, Homa, Meurgey, Alexandra, Saffroy, Raphaël, Guillemot, Delphine, Pierron, Gaëlle, Sievers, Philipp, and Varlet, Pascale

Published
2023
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4. CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population

Author

Tauziède-Espariat, Arnault, Uro-Coste, Emmanuelle, Sievers, Philipp, Nicaise, Yvan, Mariet, Cassandra, Siegfried, Aurore, Pierron, Gaëlle, Guillemot, Delphine, Benzakoun, Joseph, Pallud, Johan, Roques, Margaux, Bonneville, Fabrice, Larrieu-Ciron, Delphine, Chaynes, Patrick, Saffroy, Raphaël, Hamelin, Jocelyne, Hasty, Lauren, Métais, Alice, Chrétien, Fabrice, Kool, Marcel, Gojo, Johannes, and Varlet, Pascale

Published
2023
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6. Disseminated diffuse midline gliomas, H3K27-altered mimicking diffuse leptomeningeal glioneuronal tumors: a diagnostical challenge!

Author

Tauziède-Espariat, Arnault, Siegfried, Aurore, Uro-Coste, Emmanuelle, Nicaise, Yvan, Castel, David, Sevely, Annick, Gambart, Marion, Boetto, Sergio, Hasty, Lauren, Métais, Alice, Chrétien, Fabrice, Benzakoun, Joseph, Puget, Stéphanie, Grill, Jacques, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Ebrahimi, Azadeh, and Varlet, Pascale

Published
2022
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7. A recurrent RYR1 mutation associated with early-onset hypotonia and benign disease course

Author

Biancalana, Valérie, Rendu, John, Chaussenot, Annabelle, Mecili, Helen, Bieth, Eric, Fradin, Mélanie, Mercier, Sandra, Michaud, Maud, Nougues, Marie-Christine, Pasquier, Laurent, Sacconi, Sabrina, Romero, Norma B., Marcorelles, Pascale, Authier, François Jérôme, Gelot Bernabe, Antoinette, Uro-Coste, Emmanuelle, Cances, Claude, Isidor, Bertrand, Magot, Armelle, Minot-Myhie, Marie-Christine, Péréon, Yann, Perrier-Boeswillwald, Julie, Bretaudeau, Gilles, Dondaine, Nicolas, Bouzenard, Alison, Pizzimenti, Mégane, Eymard, Bruno, Ferreiro, Ana, Laporte, Jocelyn, Fauré, Julien, and Böhm, Johann

Published
2021
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8. The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of “CNS tumors with BCOR internal tandem duplication”

Author

Tauziède-Espariat, Arnault, Pierron, Gaëlle, Siegfried, Aurore, Guillemot, Delphine, Uro-Coste, Emmanuelle, Nicaise, Yvan, Castel, David, Catalaa, Isabelle, Larrieu-Ciron, Delphine, Chaynes, Patrick, de Barros, Amaury, Nicolau, Julien, Gareton, Albane, Lechapt, Emmanuèle, Chrétien, Fabrice, Bourdeaut, Franck, Doz, François, Bouchoucha, Yassine, Grill, Jacques, Beccaria, Kévin, Boddaert, Nathalie, Saffroy, Raphaël, Pagès, Mélanie, and Varlet, Pascale

Published
2020
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11. Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

Author

Ceccom, Johnatan, primary, Loukh, Najat, additional, Lauwers-Cances, Valérie, additional, Touriol, Christian, additional, Nicaise, Yvan, additional, Gentil, Catherine, additional, Uro-Coste, Emmanuelle, additional, Pitson, Stuart, additional, Maurage, Claude Alain, additional, Duyckaerts, Charles, additional, Cuvillier, Olivier, additional, and Delisle, Marie-Bernadette, additional

Published
2014
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12. Pediatric methylation class HGNET-MN1: unresolved issues with terminology and grading.

Author

Tauziède-Espariat, Arnault, Pagès, Mélanie, Roux, Alexandre, Siegfried, Aurore, Uro-Coste, Emmanuelle, Nicaise, Yvan, Sevely, Annick, Gambart, Marion, Boetto, Sergio, Dupuy, Martin, Richard, Pomone, Perbet, Romain, Vinchon, Matthieu, Caron, Sabine, Andreiuolo, Felipe, Gareton, Albane, Lechapt, Emmanuèle, Chrétien, Fabrice, Puget, Stéphanie, and Grill, Jacques

Subjects
CENTRAL nervous system tumors, METHYLATION
Abstract

High-grade neuroepithelial tumor with I MN1 i alteration (HGNET- I MN1 i ) is a rare, recently described central nervous system (CNS) entity with a distinct methylation profile, which was formerly part of CNS-primary neuroepithelial tumors (PNET). HGNET- I MN1 i affects children (77% of reported cases [[1]-[5]]) and are characterized by a recurrent fusion implicating the I MN1 i (meningioma 1) gene [[1]]. Children with HGNET- I MN1 i present a favourable outcome with 88.0% survival (median follow-up of 65.5 months), although 48.0% presented with tumor progression. Analysis of correlation between malignant criteria defined in astroblastoma applied to HGNET- MN1 with overall survival and progression-free survival. [Extracted from the article]

Published
2019
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13. Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.

Author

Tauziède-Espariat A, Siegfried A, Nicaise Y, Kergrohen T, Sievers P, Vasiljevic A, Roux A, Dezamis E, Benevello C, Machet MC, Michalak S, Puiseux C, Llamas-Gutierrez F, Leblond P, Bourdeaut F, Grill J, Dufour C, Guerrini-Rousseau L, Abbou S, Dangouloff-Ros V, Boddaert N, Saffroy R, Hasty L, Wahler E, Pagès M, Andreiuolo F, Lechapt E, Chrétien F, Blauwblomme T, Beccaria K, Pallud J, Puget S, Uro-Coste E, and Varlet P

Subjects
Adolescent, Adult, Child, Child, Preschool, DNA Methylation genetics, Ependymoma classification, Ependymoma metabolism, Ependymoma pathology, Female, Gene Fusion genetics, Genotype, Glial Fibrillary Acidic Protein metabolism, Humans, Infant, Male, NF-kappa B metabolism, Neural Cell Adhesion Molecule L1 metabolism, Nuclear Receptor Coactivator 1 genetics, Nuclear Receptor Coactivator 2 genetics, Phenotype, Supratentorial Neoplasms classification, Supratentorial Neoplasms metabolism, Supratentorial Neoplasms pathology, Trans-Activators genetics, Transcription Factor RelA genetics, Tumor Suppressor Proteins genetics, Young Adult, Ependymoma genetics, Proteins genetics, Supratentorial Neoplasms genetics
Abstract

The cIMPACT-NOW Update 7 has replaced the WHO nosology of "ependymoma, RELA fusion positive" by "Supratentorial-ependymoma, C11orf95-fusion positive". This modification reinforces the idea that supratentorial-ependymomas exhibiting fusion that implicates the C11orf95 (now called ZFTA) gene with or without the RELA gene, represent the same histomolecular entity. A hot off the press molecular study has identified distinct clusters of the DNA methylation class of ZFTA fusion-positive tumors. Interestingly, clusters 2 and 4 comprised tumors of different morphologies, with various ZFTA fusions without involvement of RELA. In this paper, we present a detailed series of thirteen cases of non-RELA ZFTA-fused supratentorial tumors with extensive clinical, radiological, histopathological, immunohistochemical, genetic and epigenetic (DNA methylation profiling) characterization. Contrary to the age of onset and MRI aspects similar to RELA fusion-positive EPN, we noted significant histopathological heterogeneity (pleomorphic xanthoastrocytoma-like, astroblastoma-like, ependymoma-like, and even sarcoma-like patterns) in this cohort. Immunophenotypically, these NFκB immunonegative tumors expressed GFAP variably, but EMA constantly and L1CAM frequently. Different gene partners were fused with ZFTA: NCOA1/2, MAML2 and for the first time MN1. These tumors had epigenetic homologies within the DNA methylation class of ependymomas-RELA and were classified as satellite clusters 2 and 4. Cluster 2 (n = 9) corresponded to tumors with classic ependymal histological features (n = 4) but also had astroblastic features (n = 5). Various types of ZFTA fusions were associated with cluster 2, but as in the original report, ZFTA:MAML2 fusion was frequent. Cluster 4 was enriched with sarcoma-like tumors. Moreover, we reported a novel anatomy of three ZFTA:NCOA1/2 fusions with only 1 ZFTA zinc finger domain in the putative fusion protein, whereas all previously reported non-RELA ZFTA fusions have 4 ZFTA zinc fingers. All three cases presented a sarcoma-like morphology. This genotype/phenotype association requires further studies for confirmation. Our series is the first to extensively characterize this new subset of supratentorial ZFTA-fused ependymomas and highlights the usefulness of ZFTA FISH analysis to confirm the existence of a rearrangement without RELA abnormality., (© 2021. The Author(s).)

Published
2021
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