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Start Over Author "Schwendemann G" Journal acta neuropathologica
7 results on '"Schwendemann G"'

6. Pathological alterations of ependyma and choroid plexus after experimental cerebral infection of mice with Sendai virus

Author

J. Löhler and Schwendemann G

Subjects
Male, Pathology, medicine.medical_specialty, Fluorescent Antibody Technique, Vacuole, Biology, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Mice, Ependyma, medicine, Animals, Plexus, Paramyxoviridae Infections, biology.organism_classification, Virology, Sendai virus, Parainfluenza Virus 1, Human, Choroiditis, Microscopy, Electron, medicine.anatomical_structure, Vacuolization, Cytoplasm, Choroid Plexus, Choroid plexus, Female, Neurology (clinical)
Abstract

The effects of intracerebral inoculation of Sendai virus into young adult mice were investigated by immunofluorescence, light, and electron microscopy. Immunofluorescence of virus-specific antigens was maximal on the third day after inoculation, revealing infection of leptomeninges, ependyma, and choroid plexus. Histologically, meningitis, ependymitis, and choroiditis occurred between the second and third days. The choroiditis was associated with formation of vacuoles within the cytoplasm of epithelial cells. The vacuoles reached diameters up to 50 micrometer. The ubiquitous vacuolization of plexus epithelia resulted in a honeycomb-like pattern. Opaque viral inclusions were visible within the cytoplasm of choroidal and ependymal epithelium as well as in mononuclear inflammatory cells. On electron microscopy, they were composed of intracytoplasmic nucleocapsid accumulations. Viria lay free between microvilli of plexus epithelial cells, and budding virus structures were observed at cellular surfaces. Occasionally, complete viria occurred in the cytoplasm of plexus epithelial cells and were surrounded by a unit membrane from which they appeared to arise by budding. The formation of this small cavity can be interpreted as the first stage of vacuole formation.

Published
1979

7. Lymphocyte inclusions in the juvenile type of generalized ceroid-lipofuscinosis. An electron microscopic study.

Author

Schwendemann G

Subjects
Adolescent, Child, Humans, Microscopy, Electron, Vacuoles ultrastructure, Inclusion Bodies ultrastructure, Lipidoses pathology, Lymphocytes ultrastructure
Abstract

Peripheral blood lymphocytes exhibiting cytoplasmic vacuoles from eight patients with the juvenile type of generalized ceroid-lipofuscinosis were investigated by electron microscopy. Osmiophilic inclusions could be demonstrated in the vacuoles and occasionally in the cytoplasm proper, revealing a fingerprint-like ultrastructural pattern or a less defined dense granular material, sometimes with an osmiophobic component adjoined. The inclusions are compared with those demonstrated in seven of the cases by earlier investigations of rectal biopsies in a variety of cell types, mainly in nerve cells. Discrimination is attempted between the lymphocyte inclusions and "parallel tubular arrays" regarded as representing a regular lymphocyte constituent.

Published
1976
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