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Your search keyword '"Schuelke, M."' showing total 5 results
Start Over Author "Schuelke, M." Journal acta neuropathologica
5 results on '"Schuelke, M."'

2. Atypical NMDA receptor expression in a diffuse astrocytoma, MYB- or MYBL1-altered as a trigger for autoimmune encephalitis.

Author

Nikolaus M, Koch A, Stenzel W, Elezkurtaj S, Sahm F, Tietze A, Stöffler L, Kreye J, Hernáiz Driever P, Thomale UW, Kaindl AM, Schuelke M, and Knierim E

Subjects
Humans, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-myb, Receptors, N-Methyl-D-Aspartate genetics, Trans-Activators, Astrocytoma genetics, Encephalitis genetics
Published
2022
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5. Increased mRNA expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne muscular dystrophy.

Author

von Moers A, Zwirner A, Reinhold A, Brückmann O, van Landeghem F, Stoltenburg-Didinger G, Schuppan D, Herbst H, and Schuelke M

Subjects
Adolescent, Child, Child, Preschool, DNA Mutational Analysis, Electrophoresis methods, Humans, Immunohistochemistry methods, Male, Muscles drug effects, Muscles enzymology, Muscular Dystrophy, Duchenne genetics, Platelet Endothelial Cell Adhesion Molecule-1 metabolism, RNA, Antisense pharmacology, RNA, Messenger metabolism, Reverse Transcriptase Polymerase Chain Reaction methods, Statistics, Nonparametric, Tissue Inhibitor of Metalloproteinase-1 genetics, Tissue Inhibitor of Metalloproteinase-2 genetics, Up-Regulation physiology, Vimentin metabolism, Muscular Dystrophy, Duchenne enzymology, Tissue Inhibitor of Metalloproteinase-1 metabolism, Tissue Inhibitor of Metalloproteinase-2 metabolism
Abstract

In dystrophinopathies, disease severity is generally related to the extent of muscle fibrosis. To determine whether a decrease in matrix degradation contributes to the severe fibrosis seen in Duchenne muscular dystrophy (DMD), we quantified RNA transcript numbers for the fibrolytic matrix metalloproteinases (MMP)-1 and -2 and their natural tissue inhibitors (TIMP)-1 and -2 in DMD muscle as well as in pathological and normal controls. In addition, we investigated gelatinase (MMP-2) enzyme activity by zymography. We found an up-regulation of TIMP-1, TIMP-2 and MMP-2 RNA in DMD muscle. Zymography revealed an increase in MMP-2 activity in DMD muscle homogenates, which was absent in pathological and normal controls. Therefore, besides enhanced fibrogenesis, a disturbance of matrix degradation may play a significant role in muscle fibrosis in DMD. TIMP-1 should be investigated further as a promising target for pharmacological intervention to prevent muscle fibrosis in DMD.

Published
2005
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