1. Poststroke epilepsy incidence, risk factors and treatment: German claims analysis
- Author
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Fränce Hardtstock, Nadia Foskett, Patrick Gille, Lars Joeres, Manuela Molzan, Jessica Claire Wilson, Thomas Wilke, and Martin Holtkamp
- Subjects
Adult ,Male ,medicine.medical_specialty ,Insurance Claim Review ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,Risk Factors ,Germany ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Risk factor ,Stroke ,seizures ,Aged ,Retrospective Studies ,Cerebral infarction ,business.industry ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,Symptomatic seizures ,Original Articles ,General Medicine ,Middle Aged ,medicine.disease ,stroke ,Poststroke epilepsy ,Neurology ,anticonvulsants ,Original Article ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Objectives To describe incidence, risk factors, and treatment of poststroke epilepsy (PSE) in Germany based on claims data. Methods Retrospective analysis of claims data from a German public sickness fund (AOK PLUS). Patients with acute stroke hospitalizations from January 01, 2011 and December 31, 2015 (index hospitalization) were followed for 12–72 months. Outcomes included incidence of PSE (patients with ≥2 seizure claims [during/after index hospitalization], or ≥1 seizure claim after index hospitalization), multivariate Cox‐regression analyses of time to seizure claim and death after index stroke hospitalization discharge, and antiepileptic drug (AED) treatment. Results Among 53 883 patients with stroke (mean follow‐up of 829.05 days [median 749]), 6054 (11.24%) had ≥1 seizure claim (mean age 73.95 years, 54.18% female). 2130 (35.18%) patients had a seizure claim during index hospitalization (indicative of acute symptomatic seizures). Estimated incidence of PSE (cases/1000 patient‐years) was 94.49 within 1 year. Risk of seizure claim following hospital discharge was higher in patients with hemorrhagic stroke (hazard ratio [HR] =1.13; p
- Published
- 2021
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