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Start Over Author "Bono G" Journal acta neurologica scandinavica
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10. N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.

Author

Nappi G, Facchinetti F, Martignoni E, Petraglia F, Sinforiani E, Bono G, and Genazzani AR

Subjects
Alzheimer Disease cerebrospinal fluid, Female, Humans, Male, Middle Aged, Neuropsychological Tests, beta-Lipotropin cerebrospinal fluid, Adrenocorticotropic Hormone therapeutic use, Alzheimer Disease drug therapy, Peptide Fragments therapeutic use, beta-Endorphin cerebrospinal fluid
Abstract

Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed.

Published
1988
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