1. Intraspinal primitive neuroectodermal tumour: report of two cases and review of the literature.
- Author
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Dorfmüller G, Würtz FG, Umschaden HW, Kleinert R, and Ambros PF
- Subjects
- Adolescent, Adult, Chemotherapy, Adjuvant, Combined Modality Therapy, Diagnostic Imaging, Disease Progression, Epidural Neoplasms drug therapy, Epidural Neoplasms radiotherapy, Follow-Up Studies, Humans, Male, Neuroectodermal Tumors, Primitive, Peripheral drug therapy, Neuroectodermal Tumors, Primitive, Peripheral radiotherapy, Peripheral Nervous System Neoplasms drug therapy, Peripheral Nervous System Neoplasms radiotherapy, Radiotherapy, Adjuvant, Spinal Neoplasms drug therapy, Spinal Neoplasms radiotherapy, Spinal Nerve Roots pathology, Epidural Neoplasms surgery, Neuroectodermal Tumors, Primitive, Peripheral surgery, Peripheral Nervous System Neoplasms surgery, Spinal Neoplasms surgery, Spinal Nerve Roots surgery
- Abstract
Two patients with primary intraspinal primitive neuroectodermal tumour are presented. In a 32-year-old man, the tumour evolved intradurally from a sacral nerve root. Despite repeated surgery and radiochemotherapy, the patient suffered multiple intraspinal tumour relapses and intracranial seedings, and died 29 months after the first diagnosis. In a 17-year-old male adolescent, the tumour was located in the lumbar epidural space, extending into the paraspinal muscles. Following resection and radiochemotherapy, the patient is free from disease 23 months after the initial presentation. The clinical, radiological, histopathological and cytogenetic findings of both patients are presented and the relevant literature is reviewed. Particular attention is given to the histogenetic relationship between peripheral primitive neuroectodermal tumour and Ewing's sarcoma.
- Published
- 1999
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