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Start Over Author "Grochulla F" Journal acta neurochirurgica
2 results on '"Grochulla F"'

2. Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture.

Author

Gabel, D., Preusse, D., Haritz, D., Grochulla, F., Haselsberger, K., Fankhauser, H., Ceberg, C., Peters, H., and Klotz, U.

Abstract

The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.1. The data allow the definition of amount of BSH and timing of infusion for a Phase I clinical trial protocol. [ABSTRACT FROM AUTHOR]

Published
1997
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