1. Carbocyclic analogues of inosine-5’-monophosphate: synthesis and biological activity
- Author
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Anastasia L. Khandazhinskaya, Tatiana Smirnova, Elena S. Matyugina, and Sofya Andreevskaya
- Subjects
INOSINE-5’-MONOPHOSPHATE ,biology ,Chemistry ,Carbocyclic nucleosides ,Biological activity ,Dehydrogenase ,Human type ,biology.organism_classification ,Biochemistry ,competitive inhibition ,Mycobacterium tuberculosis ,chemistry.chemical_compound ,Non-competitive inhibition ,human IMPDH II,Mycobacterium tuberculosis ,medicine ,Molecular Medicine ,Inosine ,Molecular Biology ,Hypoxanthine ,Research Article ,Biotechnology ,medicine.drug - Abstract
9-(4-Phosphonomethoxy-2-cyclopenten-1-yl)hypoxanthine and 9-(4-phosphonomethoxy-2,3-dihydroxycyclopenten-1-yl)hypoxanthine were synthesized as isosteric carbocyclic analogues of inosine-5-monophosphate. The synthesized compounds were shown to be capable of inhibiting the activity of human type II inosine-5-monophosphate dehydrogenase (IMPDH II) (IC50 = 500 M) and to have no significant effects on the growth of Mycobacterium tuberculosis.
- Published
- 2012