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Diabetes mellitus (DM) is the most prevalent metabolic disease worldwide and is associated with coronary artery disease (CAD). Therefore it is very important to find a clue to diagnose the presence of CAD as early as possible in DM patients. The aim of this study was to find any correlation between microalbuminuria (MAU) and the severity of CAD in patients with DM type 2. This was a cross sectional study that included 77 DM type 2 patients with suspected CAD that all of whom were performed coronary angiography in our hospital (from 2010 to 2011). Patients were divided into two groups, the case group (group 1) that includes patients with MAU and the control group (group 2) that include patients without MAU. Severity of CAD was estimated by using Gensini score and MAU was defined as the ratio of urine albumin to urine creatinine. Of 77 patients forty three (55.8%) were female, mean ± SD of their ages was 55.8 ± 10.3 and sixteen (21%) of them had MAU. Gensini score of case group was significantly higher than control group (94.94 ± 12 versus 33.25 ± 25.4, P

Right bundle branch block (RBBB) is considered as an important predictor of poor outcome in patients with acute myocardial infarction, but the prognostic implication of RBBB in patients with suspected coronary artery disease (CAD) is unclear. Furthermore, the association between RBBB and incidence of CAD also its influence on the severity of stenosis in coronary arteries has not been established. This study was designed to assess the relationship between RBBB and the presence and the severity of CAD in patients with suspected CAD. The study population consisted of 172 patients with RBBB and 174 patients with normal resting electrocardiography (ECG). Severity of CAD was defined as estimated Gensini score according to the degree, quantity and distribution of lesions in angiographic study. According to our study based on angiographic investigations, in patients with RBBB the prevalence of CAD was 77.3 percent versus 70.1 percent in patients with normal resting ECG (P=0.13). Also, there was no significant association between the presence of RBBB and magnitude of Gensini score (OR=0.87, P=0.62). However, male gender and history of diabetes mellitus were associated with higher Gensini score (OR=3.41; 95% CI: 1.96-5.93, P

Coronary artery calcium scoring (CACS) is a reasonable test for patients with the possibility of atherosclerosis. It can also be used for reclassifying the coronary artery disease (CAD) to the high-risk status by higher CACS and subsequently modifying the management of the patients.The purpose of this study was to investigate the association of CACS to the severity of coronary artery disease in the patients who were scheduled to perform coronary artery angiography (CAG) by tradition. CACS could be a simple, relatively cost-benefit, and noninvasive method for early screening of patients with obstructive coronary artery disease.In the present study, CAC scoring was evaluated by non-enhanced Multi-Detector Computed Tomography (MDCT) in a total 239 patient suffering from coronary artery disease. Of them, 223 patients were planned to undergo CAG based on clinical examination or other noninvasive diagnostic methods (such as MPI, ETT, EKG or Echo).Our results showed that 11 of 67 patients with a negative CACS (zero) had obstructive coronary artery disease derived from the results of CAG. We also found a significant correlation between high CACS (more than 400) and extensive obstructive CAD, except for the two patients who had only mild CAD. There was a linear correlation between CACS and the severity of CAD on the basis of Gensini score and the number of involved arteries (CC=0.507, PV400) might be a significant indicative of CAD in referring patients.

Coronary artery calcium scoring (CACS) is a reasonable test for patients with the possibility of atherosclerosis. It can also be used for reclassifying the coronary artery disease (CAD) to the high-risk status by higher CACS and subsequently modifying the management of the patients.The purpose of this study was to investigate the association of CACS to the severity of coronary artery disease in the patients who were scheduled to perform coronary artery angiography (CAG) by tradition. CACS could be a simple, relatively cost-benefit, and noninvasive method for early screening of patients with obstructive coronary artery disease. Method: In the present study, CAC scoring was evaluated by non-enhanced Multi-Detector Computed Tomography (MDCT) in a total 239 patient suffering from coronary artery disease. Of them, 223 patients were planned to undergo CAG based on clinical examination or other noninvasive diagnostic methods (such as MPI, ETT, EKG or Echo). Results: Our results showed that 11 of 67 patients with a negative CACS (zero) had obstructive coronary artery disease derived from the results of CAG. We also found a significant correlation between high CACS (more than 400) and extensive obstructive CAD, except for the two patients who had only mild CAD. There was a linear correlation between CACS and the severity of CAD on the basis of Gensini score and the number of involved arteries (CC=0.507, PV<0.001). Despite fairly high sensitivity (86.6) of zero CAC among patients with a negative score (86%), zero CACS cannot rule out the existence of obstructive coronary artery disease. As we found, increased level of CACS (>400) might be a significant indicative of CAD in referring patients. [ABSTRACT FROM AUTHOR]

Diabetes mellitus (DM) is the most prevalent metabolic disease worldwide and is associated with coronary artery disease (CAD). Therefore it is very important to find a clue to diagnose the presence of CAD as early as possible in DM patients. The aim of this study was to find any correlation between microalbuminuria (MAU) and the severity of CAD in patients with DM type 2. This was a cross sectional study that included 77 DM type 2 patients with suspected CAD that all of whom were performed coronary angiography in our hospital (from 2010 to 2011). Patients were divided into two groups, the case group (group 1) that includes patients with MAU and the control group (group 2) that include patients without MAU. Severity of CAD was estimated by using Gensini score and MAU was defined as the ratio of urine albumin to urine creatinine. Of 77 patients forty three (55.8%) were female, mean ± SD of their ages was 55.8 ± 10.3 and sixteen (21%) of them had MAU. Gensini score of case group was significantly higher than control group (94.94 ± 12 versus 33.25 ± 25.4, P<0.001). The linear regression analysis revealed urinary albumin to creatinine ratio (UA/CR) as an independent predictor for the severity of CAD (P<0.001). Based on the ROC curve, 10.25 was the best albumin level cut off point for differentiating Gensini score over and below 70. Area under curve was 0.9; sensitivity and specificity were 72% and 80%, respectively (P<0.001). According to this study, in patients with DM type2, MAU is an independent predictor of severity of coronary artery stenosis and reveals a positive correlation between MAU and the Gensini score. [ABSTRACT FROM AUTHOR]

Right bundle branch block (RBBB) is considered as an important predictor of poor outcome in patients with acute myocardial infarction, but the prognostic implication of RBBB in patients with suspected coronary artery disease (CAD) is unclear. Furthermore, the association between RBBB and incidence of CAD also its influence on the severity of stenosis in coronary arteries has not been established. This study was designed to assess the relationship between RBBB and the presence and the severity of CAD in patients with suspected CAD. The study population consisted of 172 patients with RBBB and 174 patients with normal resting electrocardiography (ECG). Severity of CAD was defined as estimated Gensini score according to the degree, quantity and distribution of lesions in angiographic study. According to our study based on angiographic investigations, in patients with RBBB the prevalence of CAD was 77.3 percent versus 70.1 percent in patients with normal resting ECG (P=0.13). Also, there was no significant association between the presence of RBBB and magnitude of Gensini score (OR=0.87, P=0.62). However, male gender and history of diabetes mellitus were associated with higher Gensini score (OR=3.41; 95% CI: 1.96-5.93, P<0.0001 and OR=3.22; 95% CI: 1.77-5.87, P<0.0001 respectively). This study suggests that although RBBB was associated with more severity of stenosis in left coronary system (LAD&LCX), but as a whole there was no association between RBBB and the presence and severity of CAD. [ABSTRACT FROM AUTHOR]