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Aim: Paracetamol is widely used by important societal groups such as pregnant women and the elderly. Paracetamol, taken in high doses especially during pregnancy, causes liver failure. The aim of our study is to investigate the effects of paracetamol, which is widely used during pregnancy, on the fetal liver. Methods: In our study, five groups of randomly selected rats from 10 Wistar Albino rats (n=2) were formed as control group, 50 mg / kg paracetamol group, 125 mg / kg paracetamol group, 250 mg / kg paracetamol group and 500 mg / kg paracetamol group. Paracetamol by gavage was given to pregnant rats in specified doses. Fetuses were taken by cesarean on the 20th day of pregnancy (10 fetuses were taken from each group). The fetus livers were then taken for biochemical analysis. Biochemically, vascular endothelial growth factor A (VEGF-A), FETU-A (FETUIN-A) (α2-heremans-schmid glikoprotein) and Sclerostin (SOST) values were examined.Results: In this study, changes in liver hepatocyte cells are seen as the dose of paracetamol increases. Regular increase is observed in VEGF-A and FETU-A. SOST increased at a dose of 250 mg / kg and decreased in the group of 500 mg / kg paracetamol. (p

Aim: This study aimed to aimed to classiffication the morphological and pathological anatomic features of patients with coccydynia.Patients and Method: Patients over 16 years of age who were admitted to Alanya Alaaddin Keykubat University Educational Research Hospital with complaints of coccydynia between April 2015 and April 2018, were included in the study. The sitting and standing coccyx and anterior-posterior pelvic radiographs of the patients were examined retrospectively.Results: It was observed that coccyx scoliosis, hypermobility, and dislocation were unrelated to sacrococcygeal angulation. There was a positive correlation between sacrococcygeal and intercoccygeal angles in the measurements of sitting and standing coccyx radiographs of the patients. There was a correlation between the length of the sacrum and length of the coccyx and also the intercoccygeal angle and coccyx length in the unoperated patients. There was a positive correlation between length of the sacrococcygeal joint and sacrococcygeal angle in males. Fusion in the sacrococcygeal joint was less in females. Conclusion: In the evaluation of patients with coccydynia, it should not be forgotten that the coccyx is a spinal segment which can move in all planes and develop pathology. Side and AP positioned sitting and standing dynamic radiography is an effective method for the detection of pathology in this patients. New classification including pathology in all three planes is needed in the classification of patients with coccydynia. We believe that our classification will eliminate this deficit.

We would like to thank our peer reviewers who take the time to submit thoughtful contributions to Acta Medica Alanya. We know how much time and effort goes into writing a good peer review, and we deeply value the input of reviewers who volunteer their time and expertise to provide essential feedback that ensures the high quality of research published in the fourth issue of the journal. Acta Medica Alanya'ya düşünceli katkılar sunmak için zaman ayıran meslektaşlarımıza teşekkür ederiz. İyi bir hakem değerlendirmesi yazmak için ne kadar zaman ve çaba harcandığını biliyoruz ve derginin dördüncü sayısında yayınlanan yüksek kalitede araştırma sağlayan temel geri bildirimleri sağlamak için zamanlarını ve uzmanlıklarını gönüllü olarak kullanan hakemlerin girdilerine derinden değer veriyoruz.