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Your search keyword '"Giovannucci Uzielli ML"' showing total 3 results
Start Over Author "Giovannucci Uzielli ML" Journal acta geneticae medicae et gemellologiae
3 results on '"Giovannucci Uzielli ML"'

3. Combined molecular and cytogenetic analysis for the rapid diagnosis of fragile X syndrome.

Author

Bussani Mastellone C, Giovannucci Uzielli ML, Grasso M, Chiurazzi P, Neri G, and Wang Q

Subjects
Female, Fragile X Syndrome genetics, Humans, Male, Blotting, Southern methods, Fragile X Syndrome diagnosis, Polymerase Chain Reaction methods
Abstract

The fragile X mutation is the result of an abnormal expansion of a CGG repeat sequence in the FMR-1 gene. Molecular techniques enable the detection of the mutation and also of the exact length of this DNA sequence, allowing the classification of the tested subjects as normal, carrier or affected. We propose a protocol of analysis that combines a method of non-radioactive PCR, Southern blotting and cytogenetic testing. This protocol can be used for screening programme of selected groups of mentally retarded individuals and for prevention studies in families at risk.

Published
1996
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