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In the title compound, C19H20N2·0.5H2O, the imidazole ring is essentially planar [maximum deviation = 0.005 (1) Å]. The imidazole ring makes dihedral angles of 67.46 (10) and 23.10 (11)° with the attached benzene and phenyl rings, respectively. The dihedral angle between the benzene and phenyl rings is 68.22 (10)°. Intermolecular O—H...N and C—H...N hydrogen bonds are found in the crystal structure.

In the title molecule, C25H26N4O, the piperidine ring adopts a chair conformation, with the plane through the four coplanar atoms making dihedral angles of 84.76 (6), 82.28 (5) and 81.91 (6)° with the pyridinering and the phenyl rings at the 2 and 6 positions, respectively. The pyridine ring makes dihedral angles of 64.13 (8) and 10.75 (8)° with the phenyl rings at the 2 and 6 positions, respectively. The dihedral angle between the two phenyl rings is 53.57 (8)°. The phenyl rings and one of the methyl groups at position 3 have an equatorial orientation. In the crystal, molecules are linked by N—H...O and C—H...O hydrogen bonds.

In the title compound, C18H18N2, the imidazole ring is essentially planar [maximum deviation = 0.004 (1) Å] and makes dihedral angles of 68.91 (8) and 20.43 (9)° with the tolyl and phenyl rings, respectively. The dihedral angle between the latter rings is 73.62 (8)°. The crystal packing is stabilized by intermolecular C—H...N hydrogen bonds.

In the title molecule, C27H19FN2, the imidazole ring is essentially planar [maximum deviation = 0.004 (1) Å] and makes dihedral angles of 62.80 (6), 36.98 (6), 33.16 (6) and 46.24 (6)°, respectively, with the substituent rings in the 1-, 2-, 4- and 5-positions. No classical hydrogen bonds are observed in the crystal structure.

In the title compound, C17H16N2·H2O, the imidazole ring is essentially planar [maximum deviation = 0.0037 (7) Å]. The imidazole ring makes dihedral angles of 80.74 (7) and 41.62 (7)° with the phenyl rings attached to the N and C atoms, respectively. The dihedral angle between the two phenyl rings is 75.83 (8)°. Intermolecular O—H...N and O—H...O hydrogen bonds are found in the crystal structure.

In the title compound, C18H17FN2O, the imidazole ring makes dihedral angles of 76.46 (7) and 40.68 (7)° with the methoxyphenyl and fluorophenyl rings, respectively. The dihedral angle between the two benzene rings is 71.25 (6)°.

In the title molecule, C18H17FN2, the imidazole ring is essentially planar [maximum deviation of 0.005 (1) Å and makes dihedral angles of 72.33 (8) and 18.71 (8)° with the methylphenyl and fluorophenyl rings, respectively. The dihedral angle between the two benzene rings is 75.05 (7)°. The crystal packing is stabilized by intermolecular C—H...N hydrogen bonds.

In the title molecule, C22H27NO, the piperidine ring adopts a chair conformation, with all substituents equatorial. The dihedral angle between the two phenyl rings is 56.90 (5)°. In the crystal, molecules are linked by weak C—H...O hydrogen bonds. A C—H...π interaction involving the phenyl ring at the 6-position is also found in the crystal structure.

The asymmetric unit of the title compound, C21H23NO4, contains two crystallographically independent molecules A and B. In both molecules, the piperidine-4-one rings adopt a distorted twist-boat conformation. The formyl group at position 1, the methoxyphenyl ring at position 2 and the methyl group at position 3 are attached equatorially. The methoxy phenyl ring at position 6 has an axial orientation. The dihedral angle between the two benzene rings is 55.27 (8)° in molecule A, and 55.29 (8)° in molecule B. In the crystal, the molecules are linked by weak C—H...O intermolecular hydrogen-bond interactions. In addition, weak C—H...π intermolecular interactions involving the benzene rings at positions 6 and 2 of molecule B are also found in the crystal structure.

In the title molecule, C21H25NO, the piperidine ring adopts a chair conformation. The benzene rings and one of the methyl groups attached to the piperidine ring have equatorial orientations. The dihedral angle between the two benzene rings is 72.53 (9)°. In the crystal, molecules are linked by N—H...O hydrogen bonds. Weak C—H...π interactions involving the benzene rings are also present in the crystal structure.

In the title molecule, C18H19NOS2·H2O, the piperidine ring adopts an envelope conformation with the methyl substituent in an equatorial position. Each of the olefinic double bonds has an E configuration. The dihedral angle between the two thiophene rings is 6.04 (14)°. The water molecule forms two donor interactions, one with the carbonyl O atom and the other to the hetero N atom. The centrosymmetric {C18H19NOS2·H2O}2 pairs thus formed are linked into a supramolecular chain via C—H...Owater contacts.

The asymmetric unit of the title compound, C21H25NO3, contains two crystallographically independent molecules (A and B). In both molecules, the piperidine ring adopts a chair conformation, with the methoxyphenyl rings attached equatorially. The dihedral angle between the two benzene rings in molecule A is 73.79 (8)°; the corresponding value in molecule B is 77.71 (8)°. The molecules are linked by N—H...O hydrogen bonds. In addition, C—H...π interactions are also found in the crystal structure.

In the title molecule, C19H19Cl2NO, the piperidine ring adopts a chair conformation and the dihedral angle between the two benzene rings is 77.23 (7)°. In the crystal structure, molecules are linked by N—H...O and C—H...O hydrogen bonds, and a weak C—H...π interaction is also observed.

In the title molecule, C20H20Cl2N2O2, the piperidine ring adopts a chair conformation and the nitroso group at position 1 has a bisectional orientation. The two benzene rings and the isopropyl group attached to the piperidine ring in positions 2, 6 and 3, respectively, have axial orientations. The dihedral angle between the two benzene rings is 21.56 (13)°. One of the Cl atoms is disordered over two positions in a 0.281 (5):0.719 (5) ratio. In the crystal structure, molecules are linked by C—H...O hydrogen bonds and a short C—H...O contact occurs within the molecule.

The asymmetric unit of the title compound, C30H46N6O4, contains one half-molecule. The C(benzene)—C(CH2)—N—C(—Me) torsion angle is −79.89 (13)° suggesting a synclinal orientation of the nitrobenzene ring with respect to the macrocycle. The conformation of the macrocycle is stabilized by intramolecular N—H...N hydrogen bonds.

In the title compound, C24H23N5O3, the oxindole ring system is nearly planar, with a dihedral angle between the two fused rings of 3.3 (1)°. In the fused pyrrolo–oxazole ring system, the oxazole and pyrrolidine rings adopt envelope conformations with the spiro C atom and one of the methylene C atoms, respectively, as the flap atoms. In the crystal, molecules are linked into a helical chain along the b axis via C—H...O interactions generating R21(7) and R22(8) ring motifs.

The crystal structure of the title compound, C9H9N3O2, features N—H...N and C—H...O interactions. The N—H...N interaction generates a chain running along the a axis and the C—H...O interaction generates a chain along the c axis. An intramolecular C—H...O interaction is also observed.

The asymmetric unit of the title compound 2C23H27N2O4+·C8H4O42−·9H2O, contains a cation, an anionon a twofold axis and four and half molecules of water, one of which is located on the twofold axis. In the cation, both fused pyrrolidine rings exhibit twisted conformations, while the piperidine rings adopt screw–boat and boat conformations. In the crystal, the components are linked by N—H...O and O—H...O hydrogen bonds. The brucinium cations form typical undulating head-to-tail ribbon structuresalong the a-axis direction, which associate with the carboxy phthalate and the water molecules.

There are two independent molecules in the asymmetric unit of the title compound, C7H5ClN4, in which the tetrazole and benzene rings are twisted by dihedral angles of 12.9 (1) and 39.8 (1)°. In the crystal, the independent molecules are connected into a tetramer by C—H...N hydrogen bonds, generating an R44(12) graph-set motif.

There are two independent molecules in the asymmetric unit of the title compound, C10H9NO3, in both of which, all non-H atoms except for the methyl C atom lie nearly in the same plane [maximum deviations = 0.094 (3) and 0.043 (2) Å]. In the crystal, each independent molecules is linked by pairs of C—H...O interactions, generating inversion dimers with R22(10) ring motifs.

In the title compound, C8H8N4, the dihedral angle between the tetrazole and benzene rings is 21.6 (1)°. An intermolecular C—H...π interaction is observed.

In the title compound, C7H4Cl2N4, the dihedral angle between the tetrazole and benzene rings is 17.2 (2)°. In the crystal, C—H...N interactions link the molecules into a flattened helical chain along the b axis.

All the non-H atoms of the title compound, C10H10N2O2, are nearly in the same plane with a maximum deviation of 0.093 (1) Å. In the crystal, adjacent molecules are linked by pairs of intermolecular N—H...O hydrogen bonds, generating inversion dimers with R22(14) ring motifs.

In the title compound, C18H14O6S, the coumarin ring system is nearly planar, with a maximum out-of-plane deviation of 0.032 (2) Å. The dihedral angle between the benzene ring and the coumarin ring system is 32.41 (8)°. The crystal packing is stabilized by intermolecular C—H...O interactions, generating C(8), C(10) and C(11) chains and an R22(10) ring. The formyl group is disordered over two sets of sites, with occupancies of 0.548 (5) and 0.452 (5).

In the title compound, C18H16N2O5S, the coumarin ring system is nearly planar, with a maximum out-of-plane deviation of 0.078 (1) Å (r.m.s. deviation = 0.046 Å). The dihedral angle between the coumarin ring system and the toluene ring (r.m.s. deviation = 0.004 Å) is 2.77 (1)°. The crystal packing is stabilized by C—H...O and N—H...O intermolecular hydrogen bonds generating C(8), C(9) and C(11) chains and R22(14), R22(23) and R43(13) ring graph sets.

In the title compound, C27H32N2O5, the morpholine ring adopts a chair conformation with two C atoms deviating by −0.656 (4) and 0.679 (3) Å from the least-squares plane defined by the rest of atoms in the ring. The tetrahydropyridine ring adopts a half-chair conformation. The molecular structure is stabilized by a strong intramolecular O—H...O interaction, generating an S(6) motif. The crystal packing is stabilized by intermolecular C—H...O interactions, generating a C(7) chain along the a axis, and R22(20) and R44(20) graph-set motifs.

In the title compound, C27H32N2O4S, the thiomorpholine ring adopts a chair conformation and the tetrahydropyridine ring is in a distorted envelope conformation. The molecular structure is stabilized by an intramolecular O—H...O interaction and the crystal packing is stabilized by an intermolecular C—H...O interaction, generating an S(6) motif and a dimer of the type R22(18), respectively.

The piperidone ring in the title compound, C23H26ClNO4, adopts a boat conformation with its two out-of-plane C atoms deviating by 0.597 (2) and 0.630 (2) Å from the least-squares plane of the rest of atoms in the ring. The two aromatic rings are roughly perpendicular to each other, making a dihedral angle of 75.1 (1)°, and a C—H...π intramolecular interaction is observed. The crystal packing is stabilized by a C—H...O intermolecular interaction, generating a chain with a C(9) motif along the a axis.

In the title compound C19H16ClF2NO2, the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544 (1) and 0.511 (1) Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C...O intermolecular contacts are observed in the structure, within a 3.00 Å range. The crystal packing is stabilized by C—H...O and C—H...F hydrogen bonds and an intermolecular π–π interaction [centroid-centroid separation of 3.783 (1) Å]. Alternating C—H...O and C—H...F intermolecular interactions generate chains running along the a axis, while a centrosymmetric R22(16) ring involving C—H...O interactions is formed centred at (1/2, 1/2, 0).

The title compound, C23H24BrNO4, crystallizes with two independent molecules per asymmetric unit. The methyl group of the ethoxycarbonyl unit is disordered over two positions, with occupancies of 0.715 (12) and 0.285 (12) in one of the independent molecules, and 0.529 (11) and 0.471 (11) in the other molecule. In one of the independent molecules, the tetrahydropyridine ring adopts a half-chair conformation, while in the other it is in a distorted envelope conformation. In each independent molecule, an intramolecular O—H...O hydrogen bond generates an S(6) ring motif. The two independent molecules are linked via C—H...O hydrogen bonds, forming a chain along the c axis.

The piperidone ring of the title compound, C14H17NO2, adopts a half-chair conformation. The crystal packing is stabilized by intermolecular C—H...O interactions, which generate a C(8) chain running along the b axis.

The thiazolidine ring and the pyrrolidine ring in the title compound, C25H26N2O2S, both adopt an envelope conformation. The seven-membered ring has a twist-chair conformation. The crystal packing is stabilized by intermolecular N—H...O hydrogen bonds.

The title compound, C28H21N3S, crystallizes with two molecules in the asymmetric unit. There are only very slight differences in the torsion angles between the two molecules. The two molecules are stabilized by intramolecular N—H...N interactions and the crystal packing is stabilized by intermolecular N—H...S interactions.

The piperidine ring of the title compound, C13H13Cl2NO, adopts an envelope conformation. Intermolecular C—H...O interactions link the molecules into a C(7) chain running along the b axis.

In the title compound, C21H24N2O3S2, the three five-membered rings adopt envelope conformations. The dihedral angle between the two aromatic rings is 68.4 (1)°. C—H...O interactions link the molecules into a chain and the chains are cross-linked via C—H...π interactions involving the methoxyphenyl ring.

In the title compound, C22H12N6O2·2H2O, the cyclopentene ring adopts an envelope conformation, with the spiro C atom bonded to the dicyano-substituted C atom deviating by 0.437 (2) Å from the plane of the remaining four atoms in the ring. The puckering and smallest displacement asymmetry parameters for the ring are q2 = 0.275 (2) Å, ϕ = 212.4 (4)° and Δs(C2) = 2.7 (2). The dihedral angle between the two indole groups is 60.1 (1)°. The structure contains intermolecular N—H...O hydrogen bonds involving the indole groups and O—H...O and O—H...N hydrogen bonds involving the water molecules.

In the title compound, C21H21ClN2O2, the dihydroisoxazole ring adopts an envelope conformation and the piperidinone ring is in a chair conformation. The dihedral angle between the two benzene rings is 84.2 (1)°. The crystal used was an inversion twin.

In the title compound, C22H23N3O2S2, the five-membered ring is planar and the C5S ring adopts a chair conformation. The crystal packing is stabilized by intermolecular N—H...O and C—H...O interactions, generating a chain and a centrosymmetric dimer, respectively.

In the title compound, C19H19F2NO, the piperidinone ring adopts a chair conformation. The crystal packing is stabilized by C—H...O and C—H...F intermolecular interactions, generating centrosymmetric dimers of R22(14) and R22(24) rings.