1. The dangerous new synthetic drug α-PVP as the hydrated chloride salt α-pyrrolidinopentiophenone hydrochloride 0.786-hydrate.
- Author
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Wood MR, Bernal I, and Lalancette RA
- Subjects
- Crystallography, X-Ray, Hydrogen Bonding, Onium Compounds chemistry, Phenethylamines pharmacology, Anions chemistry, Central Nervous System Stimulants chemical synthesis, Central Nervous System Stimulants chemistry, Designer Drugs chemical synthesis, Designer Drugs chemistry, Illicit Drugs chemical synthesis, Illicit Drugs chemistry, Onium Compounds chemical synthesis, Phenethylamines chemistry, Pyrrolidines chemical synthesis, Pyrrolidines chemistry, Salts chemical synthesis, Salts chemistry
- Abstract
α-Pyrrolidinovalerophenone (α-PVP), a dangerous designer drug, is now being marketed around the world as a harmless `bath salt', when in reality it is a powerful β-ketone phenethylamine stimulant. A sample of the free base from a recent law-enforcement seizure was crystallized as the HCl salt [systematic name: 1-(1-oxo-1-phenylpentan-2-yl)pyrrolidin-1-ium chloride 0.786-hydrate], C15H22NO(+)·Cl(-)·0.786H2O. In the crystal structure, the propyl chain is nearly perpendicular to both the phenyl ring and the carbonyl group. The hydrogen-bonding scheme involves the quaternary N atom, the Cl(-) anion and the partially occupied (0.786) water molecule, forming centrosymmetric dimers.
- Published
- 2016
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