1. Perineural meperidine blocks nerve conduction in a dose-related manner: a randomized double-blind study
- Author
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Mehmet Beyazova, B. Tarhan, Murat Zinnuroğlu, Ertan Öztürk, Jale Meray, and Kadir Kaya
- Subjects
Adult ,Male ,Narcotics ,Meperidine ,Sensory Receptor Cells ,medicine.medical_treatment ,Neural Conduction ,Motor nerve ,Action Potentials ,Sensory system ,Young Adult ,Double-Blind Method ,medicine ,Humans ,Ulnar nerve ,Saline ,Motor Neurons ,Dose-Response Relationship, Drug ,business.industry ,Snap ,General Medicine ,Middle Aged ,Compound muscle action potential ,Peripheral ,Pethidine ,Electrophysiology ,Anesthesiology and Pain Medicine ,Anesthesia ,Female ,business ,medicine.drug - Abstract
Background: Meperidine has been shown to exhibit a sensory block in peripheral nerves. However, its motor blockade ability is controversial. The aim of this study was to investigate, electroneurographically, the ability of meperidine to inhibit conduction in both sensory and motor fibres in the ulnar nerve. Materials and methods: The study was conducted in a double-blind, placebo-controlled fashion. Eighteen healthy volunteers were randomized into three groups (Saline, meperidine 1% and meperidine 2%). Three millilitre of the study solution was administered to the ulnar nerve perineurally at the level of the wrist by the guidance of a nerve stimulator. Sensory nerve action potential (SNAP) and compound motor action potential (CMAP) amplitudes were recorded. At least a 20% decrease in the initial response amplitude was accepted as a block. Results: The number of individuals with sensory and motor block with saline, meperidine 1% and meperidine 2% were 0/6, 6/6, 6/6 and 0/6, 5/6, 6/6, respectively (P
- Published
- 2009