1. Comparison of plasma α glutathione S-transferase concentrations during and after low-flow sevoflurane or isoflurane anaesthesia
- Author
-
Hideyuki Higuchi, H Wada, Masuyuki Kanno, Y Adachi, and Tetsuo Satoh
- Subjects
business.industry ,α glutathione s transferase ,General Medicine ,Nitrous oxide ,Glutathione ,Isoflurane anaesthesia ,Sevoflurane ,Fresh gas flow ,chemistry.chemical_compound ,Anesthesiology and Pain Medicine ,chemistry ,Isoflurane ,Anesthesia ,Toxicity ,medicine ,business ,medicine.drug - Abstract
Background: We evaluated the effect of low-flow sevoflurane anaesthesia, in which compound A is generated, and isoflurane anaesthesia, in which compound A is not generated (n=13 in each group), on hepatocellular integrity using a glutathione S-transferase (GST). a GST is a more sensitive and specific marker of hepatocellular damage than is aminotransferase activity and correlates better with hepatic histology. Methods: Sevoflurane or isoflurane were delivered without nitrous oxide with a fresh gas flow of 1 l/min. Concentrations of compound A in the circuit were measured hourly, and plasma a GST concentrations were measured perioperatively. Results: Mean duration of anaesthesia was 338±92 min in the sevoflurane group and 320±63 min in the isoflurane group. Mean compound A concentration in the sevoflurane group was 28.6±9.0 ppm. There was no significant difference in a GST concentrations between the sevoflurane and isoflurane groups during or after anaesthesia. Conclusion: These results indicate that low-flow sevoflurane and isoflurane anaesthesia have the same effect on hepatic function, as assessed by plasma a GST concentrations.
- Published
- 2001