1. Super-efficient in Vivo Two-Photon Photodynamic Therapy with a Gold Nanocluster as a Type I Photosensitizer
- Author
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Yuankai Hong, Lu Huang, Helin Liu, Shengcang Zhu, Zhi-Wei Wang, Yinlin Sha, Yu Wang, Rongcheng Han, Miao Zhao, Yuqiang Jiang, and Lijun Wang
- Subjects
chemistry.chemical_classification ,Reactive oxygen species ,Therapeutic Technique ,Chemistry ,medicine.medical_treatment ,General Engineering ,General Physics and Astronomy ,Photodynamic therapy ,02 engineering and technology ,In vivo toxicity ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Dihydrolipoic acid ,Two-photon excitation microscopy ,In vivo ,medicine ,Biophysics ,General Materials Science ,Photosensitizer ,0210 nano-technology - Abstract
Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic technique that can induce the regression of targeted lesions via generating excess cytotoxic reactive oxygen species. However, due to the limited penetration depth of visible excitation light and the intrinsic hypoxia microenvironment of solid tumors, the efficacy of PDT in the treatment of cancer, especially deep-seated or large tumors, is unsatisfactory. Herein, we developed an efficient in vivo PDT system based on a nanomaterial, dihydrolipoic acid coated gold nanocluster (AuNC@DHLA), that combined the advantages of large penetration depth in tissue, extremely high two-photon (TP) absorption cross section (σ2 ∼ 106 GM), efficient ROS generation, a type I photochemical mechanism, and negligible in vivo toxicity. With AuNC@DHLA as the photosensitizer, highly efficient in vivo TP-PDT has been achieved.
- Published
- 2019