1. Peptide-Programmable Nanoparticle Superstructures with Tailored Electrocatalytic Activity
- Author
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Kang, Eun Sung, Kim, Yong-Tae, Ko, Young-Seon, Kim, Nam Hyeong, Cho, Geonhee, Huh, Yang Hoon, Kim, Ji-Hun, Nam, Jiyoung, Thach, Trung Thanh, Youn, David, Kim, Young Dok, Yun, Wan Soo, DeGrado, William F, Kim, Sung Yeol, Hammond, Paula T, Lee, Jaeyoung, Kwon, Young-Uk, Ha, Don-Hyung, and Kim, Yong Ho
- Subjects
Nanotechnology ,Bioengineering ,Amino Acid Sequence ,Catalysis ,Electricity ,Gold ,Models ,Molecular ,Nanoparticles ,Nanotubes ,Carbon ,Oxidation-Reduction ,Oxygen ,Peptides ,Platinum ,supramolecular protein self-assembly ,artificialy designed peptide ,nanoparticle superstructure ,electron tomography ,peptide-based superstructure 3-D reconstruction ,peptide-based catalyst ,electrocatalytic oxygen reduction ,Nanoscience & Nanotechnology - Abstract
Biomaterials derived via programmable supramolecular protein assembly provide a viable means of constructing precisely defined structures. Here, we present programmed superstructures of AuPt nanoparticles (NPs) on carbon nanotubes (CNTs) that exhibit distinct electrocatalytic activities with respect to the nanoparticle positions via rationally modulated peptide-mediated assembly. De novo designed peptides assemble into six-helix bundles along the CNT axis to form a suprahelical structure. Surface cysteine residues of the peptides create AuPt-specific nucleation site, which allow for precise positioning of NPs onto helical geometries, as confirmed by 3-D reconstruction using electron tomography. The electrocatalytic model system, i.e., AuPt for oxygen reduction, yields electrochemical response signals that reflect the controlled arrangement of NPs in the intended assemblies. Our design approach can be expanded to versatile fields to build sophisticated functional assemblies.
- Published
- 2018