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6 results on '"Salonen, Jarno"'

2. Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor

Author

Fontana, Flavia, primary, Fusciello, Manlio, additional, Groeneveldt, Christianne, additional, Capasso, Cristian, additional, Chiaro, Jacopo, additional, Feola, Sara, additional, Liu, Zehua, additional, Mäkilä, Ermei M., additional, Salonen, Jarno J., additional, Hirvonen, Jouni T., additional, Cerullo, Vincenzo, additional, and Santos, Hélder A., additional

Published
2019
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3. Microfluidic Assembly of a Multifunctional Tailorable Composite System Designed for Site Specific Combined Oral Delivery of Peptide Drugs

Author

Araújo, Francisca, primary, Shrestha, Neha, additional, Shahbazi, Mohammad-Ali, additional, Liu, Dongfei, additional, Herranz-Blanco, Bárbara, additional, Mäkilä, Ermei M., additional, Salonen, Jarno J., additional, Hirvonen, Jouni T., additional, Granja, Pedro L., additional, Sarmento, Bruno, additional, and Santos, Hélder A., additional

Published
2015
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6. Inhibition of Influenza A Virus Infection in Vitroby Saliphenylhalamide-Loaded Porous Silicon Nanoparticles

Author

Bimbo, Luis M., Denisova, Oxana V., Mäkilä, Ermei, Kaasalainen, Martti, De Brabander, Jef K., Hirvonen, Jouni, Salonen, Jarno, Kakkola, Laura, Kainov, Denis, and Santos, Hélder A.

Abstract

Influenza A viruses (IAVs) cause recurrent epidemics in humans, with serious threat of lethal worldwide pandemics. The occurrence of antiviral-resistant virus strains and the emergence of highly pathogenic influenza viruses have triggered an urgent need to develop new anti-IAV treatments. One compound found to inhibit IAV, and other virus infections, is saliphenylhalamide (SaliPhe). SaliPhe targets host vacuolar-ATPase and inhibits acidification of endosomes, a process needed for productive virus infection. The major obstacle for the further development of SaliPhe as antiviral drug has been its poor solubility. Here, we investigated the possibility to increase SaliPhe solubility by loading the compound in thermally hydrocarbonized porous silicon (THCPSi) nanoparticles. SaliPhe-loaded nanoparticles were further investigated for the ability to inhibit influenza A infection in human retinal pigment epithelium and Madin-Darby canine kidney cells, and we show that upon release from THCPSi, SaliPhe inhibited IAV infection in vitroand reduced the amount of progeny virus in IAV-infected cells. Overall, the PSi-based nanosystem exhibited increased dissolution of the investigated anti-IAV drug SaliPhe and displayed excellent in vitrostability, low cytotoxicity, and remarkable reduction of viral load in the absence of organic solvents. This proof-of-principle study indicates that PSi nanoparticles could be used for efficient delivery of antivirals to infected cells.

Published
2013
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