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Your search keyword '"Gao, Chunyue"' showing total 3 results
Start Over Author "Gao, Chunyue" Journal acs nano
3 results on '"Gao, Chunyue"'

2. Y2O3Nanoparticles Caused Bone Tissue Damage by Breaking the Intracellular Phosphate Balance in Bone Marrow Stromal Cells

Author

Gao, Chunyue, Jin, Yi, Jia, Guang, Suo, Xiaomin, Liu, Huifang, Liu, Dandan, Yang, Xinjian, Ge, Kun, Liang, Xing-Jie, Wang, Shuxiang, and Zhang, Jinchao

Abstract

Y2O3nanoparticles (NPs) have become great promising products for numerous applications in nanoscience especially for biomedical application, therefore increasing the probability of human exposure and gaining wide attention in biosecurity. It is well known that rare earth (RE) materials are deposited in the bone and excreted very slowly. Nevertheless, the effect of Y2O3-based NPs on bone metabolism has not been exactly known yet. In the present study, the effects of Y2O3NPs on bone marrow stromal cells (BMSCs) and bone metabolism in mice after intravenous injection were studied. The results demonstrated that Y2O3NPs could be taken up into BMSCs and localized in acidifying intracellular lysosomes and underwent dissolution and transformation from Y2O3to YPO4, which could lead to a break in the intracellular phosphate balance and induce lysosomal- and mitochondrial-dependent apoptosis pathways. Furthermore, after being administered to mice, a higher concentration of yttrium occurred in bone, which caused the apoptosis of bone cells and induced the destruction of bone structure. However, the formation of a YPO4coating on the surface of Y2O3NPs by pretreatment of Y2O3NPs in lysosome-simulated body fluid could observably decrease the toxicity in vivoand in vitro. This study may be useful for practical application of Y2O3NPs in the biomedical field.

Published
2019
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3. Y 2 O 3 Nanoparticles Caused Bone Tissue Damage by Breaking the Intracellular Phosphate Balance in Bone Marrow Stromal Cells.

Author

Gao C, Jin Y, Jia G, Suo X, Liu H, Liu D, Yang X, Ge K, Liang XJ, Wang S, and Zhang J

Subjects
Animals, Apoptosis, Bone Marrow Cells metabolism, Cathepsins metabolism, Cells, Cultured, Female, Lysosomes drug effects, Lysosomes metabolism, Mice, Mice, Inbred ICR, Mitochondria genetics, Mitochondria metabolism, Nanoparticles chemistry, Yttrium chemistry, Yttrium pharmacokinetics, Bone Marrow Cells drug effects, Nanoparticles toxicity, Phosphates metabolism, Yttrium toxicity
Abstract

Y 2 O 3 nanoparticles (NPs) have become great promising products for numerous applications in nanoscience especially for biomedical application, therefore increasing the probability of human exposure and gaining wide attention in biosecurity. It is well known that rare earth (RE) materials are deposited in the bone and excreted very slowly. Nevertheless, the effect of Y 2 O 3 -based NPs on bone metabolism has not been exactly known yet. In the present study, the effects of Y 2 O 3 NPs on bone marrow stromal cells (BMSCs) and bone metabolism in mice after intravenous injection were studied. The results demonstrated that Y 2 O 3 NPs could be taken up into BMSCs and localized in acidifying intracellular lysosomes and underwent dissolution and transformation from Y 2 O 3 to YPO 4 , which could lead to a break in the intracellular phosphate balance and induce lysosomal- and mitochondrial-dependent apoptosis pathways. Furthermore, after being administered to mice, a higher concentration of yttrium occurred in bone, which caused the apoptosis of bone cells and induced the destruction of bone structure. However, the formation of a YPO 4 coating on the surface of Y 2 O 3 NPs by pretreatment of Y 2 O 3 NPs in lysosome-simulated body fluid could observably decrease the toxicity in vivo and in vitro. This study may be useful for practical application of Y 2 O 3 NPs in the biomedical field.

Published
2019
Full Text
View/download PDF

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