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Your search keyword '"Li, Guilin"' showing total 8 results
Start Over Author "Li, Guilin" Journal acs chemical neuroscience
8 results on '"Li, Guilin"'

1. Gallic Acid Improves Comorbid Chronic Pain and Depression Behaviors by Inhibiting P2X7 Receptor-Mediated Ferroptosis in the Spinal Cord of Rats

Author

Yang, Runan, primary, Shi, Liran, additional, Si, Han, additional, Hu, Zihui, additional, Zou, Lifang, additional, Li, Lin, additional, Xu, Xiumei, additional, Schmalzing, Günther, additional, Nie, Hong, additional, Li, Guilin, additional, Liu, Shuangmei, additional, Liang, Shangdong, additional, and Xu, Changshui, additional

Published
2023
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2. Correction to “Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression”

Author

Li, Lin, primary, Zou, Yuting, additional, Liu, Baoe, additional, Yang, Runan, additional, Yang, Jingjian, additional, Sun, Minghao, additional, Li, Zijing, additional, Xu, Xiumei, additional, Li, Guilin, additional, Liu, Shuangmei, additional, Greffrath, Wolfgang, additional, Treede, Rolf-Detlef, additional, Li, Guodong, additional, and Liang, Shangdong, additional

Published
2022
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3. Correction to Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression

Author

Li, Lin, primary, Zou, Yuting, additional, Liu, Baoe, additional, Yang, Runan, additional, Yang, Jingjian, additional, Sun, Minghao, additional, Li, Zijing, additional, Xu, Xiumei, additional, Li, Guilin, additional, Liu, Shuangmei, additional, Greffrath, Wolfgang, additional, Treede, Rolf-Detlef, additional, Li, Guodong, additional, and Liang, Shangdong, additional

Published
2021
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4. LncRNA UC.360+ shRNA Improves Diabetic Cardiac Sympathetic Dysfunction Mediated by the P2X4 Receptor in the Stellate Ganglion

Author

Shi, Liran, primary, Sun, Minghao, additional, Ren, Xinlu, additional, Li, Zijing, additional, Yang, Runan, additional, Xu, Xiumei, additional, Li, Lin, additional, Li, Guilin, additional, Liu, Shuangmei, additional, Schmalzing, Günther, additional, Nie, Hong, additional, Li, Guodong, additional, and Liang, Shangdong, additional

Published
2021
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5. Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression

Author

Li, Lin, primary, Zou, Yuting, additional, Liu, Baoe, additional, Yang, Runan, additional, Yang, Jingjian, additional, Sun, Minghao, additional, Li, Zijing, additional, Xu, Xiumei, additional, Li, Guilin, additional, Liu, Shuangmei, additional, Greffrath, Wolfgang, additional, Treede, Rolf-Detlef, additional, Li, Guodong, additional, and Liang, Shangdong, additional

Published
2020
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6. The Inhibition by Guanfu Base A of Neuropathic Pain Mediated by P2Y12 Receptor in Dorsal Root Ganglia

Author

Zou, Lifang, primary, Yu, Kehua, additional, Fan, Yang, additional, Cao, Suixia, additional, Liu, Shuangmei, additional, Shi, Liran, additional, Li, Lin, additional, Yuan, Huilong, additional, Yang, Runan, additional, Yi, Zhihua, additional, Gao, Yun, additional, Li, Guilin, additional, Greffrath, Wolfgang, additional, Treede, Rolf-Detlef, additional, Li, Man, additional, Xu, Hong, additional, Zhang, Chunping, additional, and Liang, Shangdong, additional

Published
2018
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8. The Inhibition by Guanfu Base A of Neuropathic Pain Mediated by P2Y 12 Receptor in Dorsal Root Ganglia.

Author

Zou L, Yu K, Fan Y, Cao S, Liu S, Shi L, Li L, Yuan H, Yang R, Yi Z, Gao Y, Li G, Greffrath W, Treede RD, Li M, Xu H, Zhang C, and Liang S

Subjects
Animals, Constriction, Pathologic drug therapy, Constriction, Pathologic metabolism, Cyclic AMP metabolism, Disease Models, Animal, Ganglia, Spinal metabolism, Glial Fibrillary Acidic Protein metabolism, HEK293 Cells, Humans, MAP Kinase Signaling System drug effects, Male, Neuralgia metabolism, RNA, Messenger metabolism, Random Allocation, Rats, Sprague-Dawley, Receptors, Purinergic P2Y12 metabolism, Sciatic Nerve, Tumor Necrosis Factor-alpha metabolism, Analgesics pharmacology, Ganglia, Spinal drug effects, Heterocyclic Compounds, 4 or More Rings pharmacology, Neuralgia drug therapy, Receptors, Purinergic P2 metabolism
Abstract

Activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRG) is involved in mechanical and thermal hyperalgesia. The upregulated P2Y 12 receptor expressed in SGCs of the DRG participates in the nociceptive transmission of neuropathic pain. Guanfu base A (GFA) has been reported to exhibit antiarrhythmic and anti-inflammatory effects. In this study, we explored the effects of GFA on P2Y 12 receptor-mediated mechanical and thermal hyperalgesia in chronic constriction injury (CCI) rats. Sprague-Dawley rats were randomly divided into sham operation group (Sham), CCI operation group (CCI), CCI rats treated with guanfu base A group (CCI + GFA) and control rats treated with GFA group (Ctrl + GFA). Mechanical withdrawal threshold and thermal withdrawal latency were measured. P2Y 12 expression in L4-L6 dorsal root ganglion (DRG) was detected by quantitative real-time PCR and Western blot. After CCI treatment, mechanical and thermal hyperalgesia and the expression values of P2Y 12 receptor mRNA and protein in DRG were increased. Dual-labeling immunofluorescence showed that the coexpression of P2Y 12 receptor and glial fibrillary acidic protein (GFAP) in the DRG of CCI rats was increased compared to sham rats. GFA relieved mechanical and thermal hyperalgesia in the CCI rats, decreased the expression of P2Y 12 mRNA and protein and phosphorylation of p38 MAPK in the DRG, and increased the ADP-downregulated cAMP concentrations in HEK293 cells transfected with P2Y 12 plasmid. After CCI rats were treated with GFA, the coexpression of P2Y 12 receptor and GFAP in the DRG was significantly decreased compared to the untreated CCI group. Thus, downregulating the P2Y 12 receptor relieved mechanical and thermal hyperalgesia in the CCI rats.

Published
2019
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