1. Alzheimer's disease: pathophysiology and applications of magnetic nanoparticles as MRI theranostic agents.
- Author
-
Amiri H, Saeidi K, Borhani P, Manafirad A, Ghavami M, and Zerbi V
- Subjects
- Alzheimer Disease pathology, Amyloid beta-Peptides metabolism, Drug Delivery Systems, Ferric Compounds therapeutic use, Humans, Magnetic Resonance Imaging instrumentation, Alzheimer Disease physiopathology, Alzheimer Disease therapy, Amyloid beta-Peptides adverse effects, Amyloid beta-Peptides chemistry, Magnetic Resonance Imaging methods, Magnetite Nanoparticles therapeutic use
- Abstract
Alzheimer's disease (AD) is the most common form of dementia. During the recent decade, nanotechnology has been widely considered, as a promising tool, for theranosis (diagnosis and therapy) of AD. Here we first discuss pathophysiology and characteristics of AD with a focus on the amyloid cascade hypothesis. Then magnetic nanoparticles (MNPs) and recent works on their applications in AD, focusing on the superparamagnetic iron oxide nanoparticles (SPIONs), are reviewed. Furthermore, the amyloid-nanoparticle interaction is highlighted, with the scope to be highly considered by the scientists aiming for diagnostics and/or treatment of AD employing nanoparticles. Furthermore, recent findings on the "ignored" parameters (e.g., effect of protein "corona" at the surface of nanoparticles on amyloid-β (Aβ) fibrillation process) are discussed.
- Published
- 2013
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