1. Palladium-Catalyzed Iodofluorination of Alkenes Using Fluoro-Iodoxole Reagent
- Author
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Miguel Angel Cortes, Nadia O. Ilchenko, and Kálmán J. Szabó
- Subjects
inorganic chemicals ,chemistry.chemical_classification ,Allylic rearrangement ,010405 organic chemistry ,Alkene ,chemistry.chemical_element ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry ,Reagent ,Organic chemistry ,heterocyclic compounds ,Palladium - Abstract
The application of an air- and moisture-stable fluoroiodane reagent was investigated in the palladium-catalyzed iodofluorination reaction of alkenes. Both the iodo and fluoro substituents arise from the fluoroiodane reagent. In the case of certain palladium catalysts, the alkene substrates undergo allylic rearrangement prior to the iodofluorination process. The reaction is faster for electron-rich alkenes than for electron-deficient ones.
- Published
- 2015
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