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Start Over Author "Eric S. Greenwood" Journal acs biomaterials science & engineering
1 results on '"Eric S. Greenwood"'

1. Evaluation of Human Performance Aiding Live Synthetically Engineered Bacteria in a Gut-on-a-Chip

Author

M. Tyler Nelson, Heidi G. Coia, Corey Holt, Eric S. Greenwood, Latha Narayanan, Peter J. Robinson, Elaine A. Merrill, Vaughn Litteral, Michael S. Goodson, Roland J. Saldanha, Matthew W. Grogg, and Camilla A. Mauzy

Subjects
Biomaterials, Biomedical Engineering
Abstract

Synbiotics are a new class of live therapeutics employing engineered genetic circuits. The rapid adoption of genetic editing tools has catalyzed the expansion of possible synbiotics, exceeding traditional testing paradigms in terms of both throughput and model complexity. Herein, we present a simplistic gut-chip model using common Caco2 and HT-29 cell lines to establish a dynamic human screening platform for a cortisol sensing tryptamine producing synbiotic for cognitive performance sustainment. The synbiotic, SYN, was engineered from the common probiotic

Published
2022

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