1. Homologous Tumor Cell-Derived Biomimetic Nano-Trojan Horse Integrating Chemotherapy with Genetherapy for Boosting Triple-Negative Breast Cancer Therapy.
- Author
-
Duan W, Shen Q, Ju L, Huang Z, Geng J, Wu Q, Yu C, and Wei J
- Subjects
- Humans, Female, Animals, Mice, Genetic Therapy, Cell Line, Tumor, Silicon Dioxide chemistry, Cell Proliferation drug effects, Drug Carriers chemistry, Triple Negative Breast Neoplasms pathology, Triple Negative Breast Neoplasms drug therapy, Triple Negative Breast Neoplasms therapy, Doxorubicin chemistry, Doxorubicin pharmacology, Nanoparticles chemistry, MicroRNAs metabolism, MicroRNAs genetics, Biomimetic Materials chemistry, Biomimetic Materials pharmacology
- Abstract
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that carries the worst prognosis and lacks specific therapeutic targets. To achieve accurate "cargos" delivery at the TNBC site, we herein constructed a novel biomimetic nano-Trojan horse integrating chemotherapy with gene therapy for boosting TNBC treatment. Briefly, we initially introduce the diselenide-bond-containing organosilica moieties into the framework of mesoporous silica nanoparticles (MONs), thereby conferring biodegradability to intratumoral redox conditions in the obtained MON
Se . Subsequently, doxorubicin (Dox) and therapeutic miR-34a are loaded into MONSe , thus achieving the combination of chemotherapy and gene-therapy. After homologous tumor cell membrane coating, the ultimate homologous tumor cell-derived biomimetic nano-Trojan horse (namely, MONSe @Dox@miR-34a@CM) can selectively enter the tumor cells in a stealth-like fashion. Notably, such a nanoplatform not only synergistically eradicated the tumor but also inhibited the proliferation of breast cancer stem-like cells (BCSCs) in vitro and in vivo . With the integration of homologous tumor cell membrane-facilitated intratumoral accumulation, excellent biodegradability, and synergistic gene-chemotherapy, our biomimetic nanocarriers hold tremendous promise for the cure of TNBC in the future.- Published
- 2024
- Full Text
- View/download PDF