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It is assumed that the socalled "One Tower" skyscraper with a height of 403.9 meters, considered in the distinctive paper, will be located in the Moscow International Business Center (MIBC) and will become one of the tallest buildings in Europe. The project of a unique object was developed in the architectural bureau "Sergey Skuratov Architects" and "GKTtechStroy" LLC (under the direction of M.I. Kelman). Generally the paper is devoted to computational studies of the stress-strain state, strength and stability ofload-bearing structures of this multifunctional residential complex with an underground parking lot. The paper provides a brief description of the natural conditions of the area of the location of the object, its load-bearing structures, characteristic and design loads, their combinations. Besides, formulation of objectives of computational research is presented. Then numerical methods, algorithms and software, which were used for computational static and dynamic analysis of skyscraper and analysis of corresponding stress-strain state are described. Further, the developed and verified advanced detailed finite element model of the coupled system "pile foundation - load­bearing structures of residential building" is considered. This model adequately reflects corresponding geometric, stiffness, inertial and load parameters and the resulting stress-strain state. Resulting parameters of the stress-strain state, strength and dynamics of load-bearing structures of "One Tower" sky­scraper with allowance for design (in accordance with design codes) combinations of vertical and wind loads and progressive collapse analysis are under consideration as well. As a result a reasonable conclusion is made about the reliability of the criterion parameters obtained by structural analysis including strength analysis, stability analysis and dynamic analysis of the loadbearing structures of the building. Computational structural analysis was performed with the use of licensed certified finite element software package ANSYS Mechanical, verified by the Russian Academy of Architecture and Construction Sciences (RAACS). Reinforcement of structures was designed in "OM SNiP Zhelezobeton" software after converting of resultant efforts from ANSYS Mechanical.