Research focusing on the scope of practice by nurse anesthetists (NAs) is limited. The purpose of this study was to examine NAs' scope of practice in Norway, and to explore whether and how this has changed during the period from 1979 to 2018. The study had a repeated crosssectional design. All members of the Norwegian Association of Nurse Anesthetists at the four time-points (1979, 1989, 1999 and 2018) were invited to participate in a questionnaire study. Inclusion criteria were education and work as an NA and currently working in Norway. Data were analyzed using the Statistical Package for the Social Sciences (SPSS). Findings indicate that the scope of NAs' practice in Norway has been increasingly restricted from 1979 to 2018 (N = 2171, P < .001). Additionally, the presence of an anesthesiologist when performing anesthesia had significantly increased during that time (39% in 1979 vs 90% in 2018). However, NAs' independent practice significantly increased in some areas, such as handling of acute situations, (i.e., handling of laryngospasm/bronchospasm [41% in 1979 versus 54% in 2018]). International and national standards underline the independent role of NAs. The development shown in our results should be addressed to avoid further restrictions of NAs' scope of practice., Competing Interests: Name: Ann-Chatrin Linqvist Leonardsen, MSc, PhD, NA Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. This author is the corresponding author of this article. Disclosures: This study was funded by the Norwegian Association of Nurse Anesthetists. The funding body did not take part in planning or conduction of the study, or in analysis of data or writing of the manuscript. Name: Sigrunn Drageset, MSc, PhD, NA Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: This study was funded by the Norwegian Association of Nurse Anesthetists. The funding body did not take part in planning or conduction of the study, or in analysis of data or writing of the manuscript. Name: Sidsel Ellingsen, MSc, PhD, NA Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: This study was funded by the Norwegian Association of Nurse Anesthetists. The funding body did not take part in planning or conduction of the study, or in analysis of data or writing of the manuscript. Name: Therese Jenssen Finjarn, MSc, NA Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: This study was funded by the Norwegian Association of Nurse Anesthetists. The funding body did not take part in planning or conduction of the study, or in analysis of data or writing of the manuscript. Name: Leiv Sandvik, PhD Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: This study was funded by the Norwegian Association of Nurse Anesthetists. The funding body did not take part in planning or conduction of the study, or in analysis of data or writing of the manuscript. Name: Marit Vassbotten Olsen, MSc, NA Contribution: This author made significant contributions to the conception, synthesis, writing, and final editing and approval of the manuscript to justify inclusion as an author. Disclosures: This study was funded by the Norwegian Association of Nurse Anesthetists. The funding body did not take part in planning or conduction of the study, or in analysis of data or writing of the manuscript, (Copyright © by the American Association of Nurse Anesthetists.)