1. Acquired Hemophilia A After Hepatic Yttrium-90 Radioembolization: A Case Report.
- Author
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Tribuzi S, Naccarato A, Pelagalli L, Covotta M, Torregiani G, Claroni C, and Forastiere E
- Subjects
- Aged, Hemophilia A etiology, Humans, Male, Carcinoma, Hepatocellular radiotherapy, Factor VII therapeutic use, Hemophilia A drug therapy, Liver Neoplasms radiotherapy, Yttrium Radioisotopes administration & dosage
- Abstract
Acquired hemophilia is a rare but potentially life-threatening bleeding disorder caused by the development of autoantibodies (inhibitors) directed against plasma coagulation factors, most frequently factor VIII. We report a case of a 65-year-old man with hepatocellular carcinoma who bled massively after a hepatic Yttrium-90 radioembolization procedure (Selective Internal Radiation Therapy with Yttrium-90 Resin Microspheres [SIRTex]). An acquired deficiency of factor VIII was diagnosed and successfully treated with recombinant activated factor VII and immunosuppression.
- Published
- 2017
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