Search

Fullerene is one of carbon allotropes with extremely low solubility in aqueous solvents and most organic solvents, but high potential of application in various areas, such as medicine, photovoltaics and materials. To overcome this obstacle, fullerene needs to be functionalized. The Prato reaction is decent synthetic method that provides N- and C-substituted fulleropyrrolidines. We optimized the conditions of the Prato reaction in order to obtain fulleropyrrolidines containing phenol (3d) and protected phenol subunits (3a, 3b). (Figure 1) The desired products were purified by dry-flash chromatography and obtained in satisfactory yields.