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Introduction: Considering the level of allergic sensitization (0, 1, ≥2 positive skin prick tests: SPT) could provide novel insight into the immune response underlying asthma, rhinitis and their comorbidity. Aim: To study how the level of allergic sensitization differs according to asthma, rhinitis and their comorbidity. Methods: Analyses were conducted in 1199 adults of the first follow-up of the Epidemiological Study on the Genetics and Environment of Asthma with available data on asthma, rhinitis, SPT, total-IgE and blood eosinophils. Participants were classified into 6 groups: no asthma, no rhinitis, non-allergic rhinitis (NAR, nasal symptoms but no report of allergic rhinitis/hay fever), allergic rhinitis (AR, nasal symptoms and report of allergic rhinitis/hay fever), asthma only, asthma + NAR, and asthma + AR. Results: Most of the participants with no respiratory symptoms or non-allergic rhinitis were not sensitized or mono-sensitized. Participants with co-morbid asthma and AR had the highest level of polysensitization. Other groups had an intermediate level of polysensitization. Interestingly eosinophils and total-IgE showed similar patterns. Conclusion: These results show a link between inflammation, polysensitization and comorbidity of asthma and rhinitis suggesting commonalities in mechanisms of Th2 inflammation and IgE response.