1. Exercise-induced immune response in patients with idiopathic pulmonary arterial hypertension
- Author
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Emilia Renk, Nicole Lüneburg, Djordje Atanackovic, Rainer H. Böger, Hans Klose, Lars Harbaum, Hans Jörg Baumann, Carsten Bokemeyer, Tim Oqueka, and Sara Yousef
- Subjects
Autoimmune disease ,medicine.medical_specialty ,business.industry ,Lymphocyte ,Inflammation ,Physical exercise ,medicine.disease ,CXCR3 ,medicine.disease_cause ,Gastroenterology ,Autoimmunity ,Pathogenesis ,medicine.anatomical_structure ,Immune system ,Internal medicine ,Immunology ,medicine ,medicine.symptom ,business - Abstract
Introduction: Perivascular inflammation and elevated levels of circulating cytokines are observed in patients idiopathic pulmonary arterial hypertension (IPAH) suggesting a potential role of inflammation and autoimmunity in the pathogenesis. Physical exercise exerts an anti-inflammatory effect in chronic cardiovascular diseases by amelioration of low-grade chronic inflammation. Methods: Patients with IPAH in WHO functional class II-III, without past or current malignant or autoimmune disease and with a current c-reactive protein level < 5 mg/dl were included. Cardiopulmonary exercise testing (CPET) was performed in patients and age-, gender- and body mass index-matched healthy subjects. Phenotypic characterization of lymphocytes was performed with multicolor flow cytometry. Results: Prior to exercise higher levels of CXCR3−/CCR6−/CCR4+ TH2 (p=0.035) and CD25high/CD127low T regulatory lymphocytes (p=0.041) as well as lower levels CXCR3+/CCR6+/CCR4− TH1/TH17 lymphocytes (p=0.007) were found in IPAH patients (n=12) compared to healthy controls (n=10). Overall, CPET provoked a transient elevation of lymphocyte number (p
- Published
- 2015