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The perfume preparation laboratory as part of Research and Development department in a chemical industry takes customer orders in form of request of making fragrance or flavors. There are many processes in laboratory; these can be classified into value added as well as non-value-added activities. The processes of making perfume oftentimes happen waiting for raw materials, stock out of raw materials, storage of excess raw materials and repeated pouring activities of raw materials. This study applies Define, Measure, Analyze, Improvement, and Control (DMAIC) methodology, to improve its productivity. The study identifies wastes in laboratory activities. The method also reduced the frequency of raw materials demand by 90% and decreased inventory process time by 90%. It also cut the trial making process consisting of 14 processes into 11 processes and time savings of 104.9 seconds.