1. Supra-Spinal Modulation Of Walking In Healthy Individuals And Persons With Multiple Sclerosis: A fNIRS Mobile Imaging Study
- Author
-
Soha Saleh, Brian M. Sandroff, Oyindamola Owoeye, Tyler Vitiello, Armand Hoxha, Guang Yue, and John DeLuca
- Subjects
Nervous system ,030506 rehabilitation ,medicine.medical_specialty ,Multiple Sclerosis ,Activities of daily living ,Population ,Walking ,Electroencephalography ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Activities of Daily Living ,medicine ,Humans ,education ,education.field_of_study ,Spectroscopy, Near-Infrared ,medicine.diagnostic_test ,Multiple sclerosis ,Motor Cortex ,Cognition ,medicine.disease ,Gait ,medicine.anatomical_structure ,0305 other medical science ,030217 neurology & neurosurgery ,Motor cortex - Abstract
Multiple sclerosis (MS) is one of the neurodegenerative diseases that damage the nervous system and inflicts cognitive and motor deficits. In motor domain, MS mainly causes slower gait resulting in challenges in activities of daily living. Premotor cortices are affected by MS, where several imaging studies have reported re-organization in the activity and connectivity of these regions. Recent advancements in mobile imaging technologies and signal processing techniques have made it possible to study supraspinal modulation of walking in able-bodied individuals and persons with injuries or neurological disorders. Functional near-infrared spectroscopy (fNIRS), for example, was used in studying dual-tasking in MS population. In the current study, we used fNIRS to record activities of premotor and supplementary motor areas in MS and healthy populations during standing and walking. Fourteen healthy controls and 14 persons with MS were tested during overground walking. Results show higher right premotor cortex activities compared with left premotor and bilateral supplementary motor areas in the MS group. In the healthy control group, activity was higher during walking in all the four studied brain regions. These results confirm the role of the premotor cortices in movement planning and in modulating walking activities; they also confirm that individuals with mild MS have a similar premotor control strategy as healthy controls while performing the same physical task.
- Published
- 2018