Search

Fluorimetric detection is widely utilized in analytical applications including pathogen detection, clinical diagnosis and DNA analysis. This method combined with lab-on-a-chip (LOC) technique provides new class of miniature and ultrasensitive bioanalytical tools and therefore new solutions are being widely developed. We present new measurement set-up for lab-on-a-chip fluorimetric detection which consists of silicon-glass LOC microreactor, detection unit with CCD-sensor, semiconductor laser module and dedicated software. Unique image-processing algorithm provides real-time fluorescence signal analysis and databasing.

Diagnostic Lab-Chip devices contains multiphase and multicomponent biochemical mixtures. For its simulation we propose multiscale flow model, which consist of macro-, meso-and micro-scale submodels. Hybrid Galerkin FEM algorithm was used solving model equations and obtain simulation results.