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In this paper, we propose a unified and analytical approach to evaluate both interference and system performance over generalized fading channels. The analytical solution proposed is quite general, applicable to envelop and power statistics, aggregate interference of arbitrary input and signal-to-interference ratio (SIR), distributions and higher order statistics, interference and system performance over generalized fading channels including simple fading channels and composed fading channels. What enables the unification of the approach is the algebra and statistic merits of Fox's H function and distribution. Finally, the unified approach is well tested and verified by Monte Carlo simulations with controllable errors.