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Gamma camera imaging is one of prevalent diagnostic imaging tool for nuclear medicine. Although gamma camera imaging widely used for diagnostic imaging, quantification of gamma camera imaging is difficult due to scattered radiation. Compton scattering is always a problematic phenomenon in gamma camera imaging. In previous study, Siemens symbia scintillation camera was modeled for assessment of septal penetration photons and validation of Monte Carlo simulation code for the Siemens scintillation camera. In this study, optimal energy window for triple energy window (TEW) scatter correction method was assessed in gamma camera for 99mTc, 131I radioisotopes using GATE simulation.

Radioimmunotherapy (RIT) is a promising approach for targeted therapy to treat intractable cancer because radionuclides are delivered more selective to tumor using monoclonal antibody, RIT can be used clinical practice with administration of murine anti-CD20. In this study, the absorbed dose of total body and red marrow of patient enrolled in RIT study was calculated.

We investigated optimized collimator designs for I-131 high energy gamma ray imaging on small animal gamma camera. The simulated structures of the pinhole collimator were evaluated by sensitivity, true, scatter and penetration count rates, and spatial resolution. The parameters, which were pinhole diameter, acceptance angle, and aperture thickness, were determined to improve image resolution with geometric conditions. In this study we showed optimized pinhole design for high energy I-131 imaging to meet the tradeoff between sensitivity and resolution