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This paper presents low cost and high specific anesthetic biosensors with functionally imprinted nanocavities on polymer films. Propofol (2,6-di-isopropylphenol) is an intravenous anesthetic, widely used in induction of anesthesia, total intravenous anesthesia and sedation of intensive care unit patients. Although the propofol concentration in blood can be detected by high-performance liquid chromatography and/or gas chromatography, these methods are time-consuming and not ease of access. In this work, we control the morphology of imprinted nanocavities on molecularly imprinted biosensors by adjusting polymer composition. Our developed biosensors have been compared with a conventional spectrophotometer to investigate surface morphology and performance of the anesthetic biosensors. The performance of the anesthetic biosensors can be enhanced by adjusting morphology of imprinted nanocavities. The newly developed biosensors have been characterized using our developed optofluidic microsystem.