1. Model based reconstruction for simultaneously imaging cerebral blood flow and De-oxygen hemoglobin distribution
- Author
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Abhishek Rege, Shanbao Tong, Nitish V. Thakor, Nan Li, and Peng Miao
- Subjects
Light ,Biomedical Engineering ,Normal Distribution ,Image processing ,Iterative reconstruction ,Rats, Sprague-Dawley ,Hemoglobins ,Speckle pattern ,Optics ,Image Processing, Computer-Assisted ,Animals ,Image resolution ,Lighting ,Physics ,business.industry ,Lasers ,Laser Speckle Imaging ,Equipment Design ,Blood flow ,Rats ,Oxygen ,Cerebral blood flow ,Cerebrovascular Circulation ,Curve fitting ,Female ,business ,Algorithms ,Biomedical engineering - Abstract
Laser speckle imaging (LSI) and optical intrinsic signal (OIS) imaging are shown to produce high resolution information of cerebral blood flow(CBF) and de-oxygen hemoglobin(dHb) respectively. However, the cortex curvature and non-uniform illumination always result in the inhomo-geneous impact and thus distort the CBF and dHb results. In this paper, we propose to extract both CBF and dHb images from raw speckle images. A parametric model for such inhomogeneity is estimated by adaptive window median-mean filtering and curve fitting technique to reconstruct the CBF and dHb image.
- Published
- 2009
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