1. Fundamental Electrical Quantities in Deep Brain Stimulation: Influence of Domain Dimensions and Boundary Conditions
- Author
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Micaela Liberti, Alessandra Paffi, T. Novellino, Francesca Apollonio, F. Maggio, Paolo Ravazzani, Marta Parazzini, and Guglielmo d'Inzeo
- Subjects
Deep brain stimulation ,Deep Brain Stimulation ,Parkinson's disease ,medicine.medical_treatment ,Finite Element Analysis ,Domain (software engineering) ,medicine ,Computer Simulation ,Patient treatment ,Laplace equations ,Boundary value problem ,Clinical efficacy ,Electrodes ,Conductivity ,Boundary conditions ,Essential tremor ,Brain ,Neurophysiology ,medicine.disease ,Electric Stimulation ,Characterization (materials science) ,Electric potential ,Brain stimulation ,Psychology ,Neuroscience - Abstract
Deep Brain Stimulation (DBS) has revealed a convincing clinical efficacy in Parkinson's diseases and essential tremor. Unfortunately, to date no clear understanding of the therapeutic mechanisms has been achieved. Characterization of the distribution of the electrical quantities inside the target areas of the central nervous system is one fundamental step ahead. Starting from the studies that so far addressed this issue, aim of this work is to quantify the role of some parameters, such as dimensions of the conducting domain and of boundary conditions, on the distribution of the fundamental electric quantities inside the brain target area.
- Published
- 2007
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