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Despite the growth of e-learning, its methods have yet to be incorporated into all educational modules within the discipline of medicine. As such, its integration into some educational methods for the study of complex diseases may benefit both students and trainees. In particular, the strategies demonstrated in blended, multimedia and web-based interactive platforms may enhance its overall communication. Cystic Fibrosis is a complex genetic disease which affects various parts of the body. These effects prove difficult to communicate through the written form alone and visual media elements are often incorporated to encourage a better understanding. However this foundational understanding of the disease has the potential to be enhanced further through the utilisation of e-learning techniques. In this paper, current content and resources in the field of e-learning for the disease Cystic Fibrosis and other complex lung diseases are compared and interrogated for possible areas of improvement and expansion. It was found that there was a lack of e-learning visualisers and simulators that demonstrated the mucus effects caused by Cystic Fibrosis within the lungs. As such, a Cystic Fibrosis visualiser and simulator was created using both 3D and web technologies and presented to medical students for evaluation. It was found that the visualiser aided in initial primary understanding of the mucus effects on the lungs, however, it was also found that it could not be used for further advanced teaching without improvements. In this way, it was established that the visualiser, in its simplicity, could be used to educate patients and families about Cystic Fibrosis mucus effects on the lungs.